Table 2.
Relationship between disease severity with physical and laboratory findings of patients (n = 76)
| Severity of disease | |||||
|---|---|---|---|---|---|
| Variables | Mild (n = 47) | Moderate (n = 22) | Severe (n = 7) | Test statistics | p values |
| Age, median (min‐max) | 39 (19–65) | 45 (23–70) | 66 (45–80) a | 17.842 b | <0.001 |
| Post hoc c : Mi vs. Mo (p = 0.154), Mi vs. S ( p < 0.001), Mo vs. S ( p = 0.025) | |||||
| TST result, n (%) | |||||
| Positive | 23 (48.9) a | 0 (0) | 0 (0) | 22.623 d | <0.001 |
| Negative | 24 (51.1) | 22 (100) | 7 (100) | ||
| TST induration diameter (mm), median (min‐max) | 9 (0–33) a | 4.5 (0–11) | 0 (0–5) | 16.895 b | <0.001 |
| Post hoc c : Mi vs. Mo ( p = 0.006), Mi vs. S ( p = 0.003), Mo vs. S (p = 0.695) | |||||
| TST induration diameter, n (%) | |||||
| 0–4 mm | 14 (29.8) | 11 (50) | 6 (85.7) | ||
| 5–9 mm | 10 (21.3) | 10 (45.5) | 1 (14.3) | ||
| 10–14 mm | 12 (25.5) | 1 (4.5) | 0 (0) | 17.287 d | 0.025 |
| 15–19 mm | 6 (12.8) | 0 (0) | 0 (0) | ||
| 20–24 mm | 2 (4.3) | 0 (0) | 0 (0) | ||
| ≥25 mm | 3 (6.4) | 0 (0) | 0 (0) | ||
| Number of BCG scars, median (min‐max) | 2 (1–3) | 1 (0–3) | 1 (0–2) | 5.748 b | 0.056 |
| Number of BCG scars, n (%) | |||||
| No scar | 0 (0) | 1 (4.5) | 2 (28.6) | ||
| 1 scar | 15 (31.9) | 11 (50.0) | 3 (42.9) | 16.209 d | 0.004 |
| 2 scars | 25 (53.2) | 4 (18.2) | 2 (28.6) | ||
| 3 scars | 7 (14.9) | 6 (27.3) | 0 (0) | ||
| Body mass index, n (%) | 0.827 d | 0.689 | |||
| <25 | 28 (59.6) | 12 (54.5) | 3 (42.9) | ||
| ≥25 | 19 (40.4) | 10 (45.5) | 4 (57.1) | ||
| Body mass index, n (%) | |||||
| 16–20 | 3 (6.4) | 0 (0) | 1 (14.3) | 4.951 d | 0.524 |
| 21–25 | 25 (53.2) | 12 (54.5) | 2 (28.6) | ||
| 26–30 | 18 (38.3) | 9 (40.9) | 4 (57.1) | ||
| 31–35 | 1 (2.1) | 1 (4.5) | 0 (0) | ||
| White blood cell count (103/μl), median (min‐max) | 6300 (3200–10 400) | 5600 (3500–9800) | 4900 (1800–18 100) | 2.423 b | 0.298 |
| White blood cell count, n (%) | |||||
| <4000 | 3 (8.1) | 3 (13.6) | 1 (14.3) | ||
| 4000–11 000 | 34 (91.9) | 19 (86.4) | 5 (71.4) | 5.888 d | 0.146 |
| 11 001–15 000 | 0 (0) | 0 (0) | 0 (0) | ||
| 15 001–20 000 | 0 (0) | 0 (0) | 1 (14.3) | ||
| Serum lymphocyte count (103/μl), median (min‐max) | 1860 (990–3100) | 1490 (810–3030) | 830 (400–1680)a | 16.155 b | <0.001 |
| Post hoc c : Mi vs. Mo (p = 0.107), Mi vs. S (p < 0.001), Mo vs. S (p = 0.058) | |||||
| Serum lymphocyte count, n (%) | 8.173 d | 0.010 | |||
| <800 | 0 (0) | 0 (0) | 2 (28.6) | ||
| 800 and above | 37 (100) | 22 (100) | 5 (71.4) | ||
| Serum lymphocyte count, n (%) | |||||
| 201–400 | 0 (0) | 0 (0) | 1 (14.3) | ||
| 401–800 | 0 (0) | 0 (0) | 1 (14.3) | ||
| 801–1000 | 1 (2.7) | 4 (18.2) | 3 (42.9) | 26.126 d | 0.001 |
| 1001–1200 | 5 (13.5) | 5 (22.7) | 1 (14.3) | ||
| 1201–1400 | 1 (2.7) | 1 (4.5) | 0 (0) | ||
| 1401–1600 | 3 (8.1) | 4 (18.2) | 0 (0) | ||
| >1600 | 27 (73.0) | 8 (36.4) | 1 (14.3) | ||
| Presence of comorbidity, n (%) | |||||
| Present | 9 (19.1) | 7 (31.8) | 6 (85.7) | 11.740 d | 0.002 |
| None | 38 (80.9) | 15 (68.2) | 1 (14.3) | ||
Abbreviations: BCG, Bacillus Calmette–Guérin; Mi, mild; Mo, moderate; S, severe; SD, standard deviation; TST, tuberculin skin test.
a
The group from which the difference originates.
b
Kruskal–Wallis H.
c
Dunn.
d
Fisher's exact test.