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. Author manuscript; available in PMC: 2022 Oct 6.
Published in final edited form as: Annu Rev Cell Dev Biol. 2021 Jul 2;37:233–256. doi: 10.1146/annurev-cellbio-120319-030049

Figure 1.

Figure 1

Components of nuclear mechanotransduction. Schematic overview (left panel) and zoomed-in section of the nuclear envelope (left panel, black box & right panel), with INM and ONM, chromatin (turquoise and gray), and the nuclear lamina (yellow and purple). LADs and the LINC are depicted in the zoomed-in view. Nuclear pore complexes (blue), the endoplasmic reticulum, and the invaginations of the nucleoplasmic reticulum are depicted in the overview panel. Abbreviations: BAF, barrier-to-autointegration factor; F-actin, fibrous actin; INM, inner nuclear membrane; LAD, lamina-associated domain; LINC, linker of nucleoskeleton and cytoskeleton complex; ONM, outer nuclear membrane; ER, endoplasmic reticulum; NR, nucleoplasmic reticulum; P, phosphorylated; SUN-1/2, Sad1p/UNC-84 1/2.