Fig. 1.

METTLs in major metazoan phyla according to NCBI search results. The metazoan cladogram is modified from the Tree of Life web project (http://tolweb.org/tree/phylogeny.html). The matrix displays the detection (gray), probable detection but with uncertain identification (striped-gray), or failure of detection (white) by the search for each METTL gene within each phylum. The number of METTL genes out of 33 total is noted in parenthesis with asterisks indicating phyla in which probable METTL sequences were either located but could not be definitively identified as specific METTL genes, or were located outside of our search in the NCBI GenBank database (e.g., Ensembl Metazoa). METTLs are listed in order of decreasing number of representatives in each phylum (left to right).