Table 1.
METTL Genes Separated by Type (i.e., DNA/RNA-modifying, protein-modifying, and unknown).
| Gene Name | NCBI ID | Aliases | Preferred Name | Target |
|---|---|---|---|---|
| DNA/RNA-modifying METTLs | ||||
| METTL1 | 4234 | C12orf1, TRM8, TRMT8, YDL201w | tRNA (guanine-N(7)-)-methyltransferase | m7G (tRNA, mRNA, miRNA) |
| METTL2 (METTL2A/B) | 339175/55798 | METL, PSENIP1 | tRNA N(3)-methylcytidine methyltransferase METTL2; methyltransferase-like protein 2 | m3C (tRNA) |
| METTL3 | 56339 | IME4, M6A, MT-A70, Spo8, hMETTL3 | N6-adenosine-methyltransferase catalytic subunit | m6A (mRNA) |
| METTL4 | 64863 | HsT661 | N(6)-adenine-specific methyltransferase METTL4 | m6A (DNA)/m6Am (snRNA) |
| METTL5 | 29081 | HSPC133, MRT72 | rRNA N6-adenosine-methyltransferase METTL5 | m6A (rRNA) |
| METTL6 | 131965 | None | tRNA N(3)-methylcytidine methyltransferase METTL6 | m3C (tRNA) |
| METTL8 | 79828 | TIP | mRNA N(3)-methylcytidine methyltransferase METTL8 | m3C (mRNA) |
| METTL14 | 57721 | None | N6-adenosine-methyltransferase noncatalytic subunit | m6A (mRNA) |
| METTL15 | 196074 | METT5D1 | 12S rRNA N4-methylcytidine (m4C) methyltransferase | m4C (rRNA) |
| METTL16 | 79066 | METT10D | RNA N6-adenosine-methyltransferase METTL16 | m6A (ncRNA, pre-mRNA, mRNA) |
| METTL19 | 152992 | TRMT44, C4orf23, TRM44 | Probable tRNA (uracil-O(2)-)-methyltransferase | 2′-O-methyluridine (tRNA) |
| METTL25B | 51093 | RRNAD1, C1orf66, CGI-41 | Ribosomal RNA adenine dimethylase domain containing 1 | m6A (rRNA) |
|
| ||||
| Protein-modifying METTLs | ||||
| METTL9 | 51108 | CGI-81, DREV, DREV1, PAP1 | Methyltransferase-like protein 9 | Unknown |
| METTL10 | 399818 | EEF1AKMT2, C10orf138, Efm4 | EEF1A lysine methyltransferase 2 | Lysine (EEF1A) |
| METTL11A | 28989 | NTMT1, AD-003, C9orf32, HOMT1A, NRMT, NRMT1, NTM1A | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal |
| METTL11B | 149281 | C1orf184, HOMT1B, NTM1B | Alpha N-terminal protein methyltransferase 1B | N-terminal |
| METTL12 | 751071 | CSKMT, CS-KMT, U99HG | Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial | Lysine (citrate synthase) |
| METTL13 | 51603 | EEF1AKNMT, 5630401D24Rik, CGI-01, DFNB26, DFNB26M, DFNM1, KIAA0859, feat | eEF1A lysine and N-terminal methyltransferase | Lysine (EEF1A) |
| METTL18 | 92342 | AsTP2, C1orf156, HPM1 | Histidine protein methyltransferase 1 homolog | Histidine |
| METTL20 | 254013 | ETFBKMT, C12orf72, ETFB-KMT | Electron transfer flavoprotein beta subunit lysine methyltransferase | Lysine (ETFβ) |
| METTL21A | 151194 | FAM119A, HCA557b, HSPA-KMT | Protein N-lysine methyltransferase METTL21A | Lysine (HSPA) |
| METTL21B | 25895 | EEF1AKMT3, FAM119B | EEF1A lysine methyltransferase 3 | Lysine (EEF1A) |
| METTL21C | 196541 | C13orf39 | Protein-lysine methyltransferase METTL21C | Lysine (VCP) |
| METTL21D | 79609 | VCPKMT, C14orf138, VCP-KMT | Protein-lysine methyltransferase METTL21D | Lysine (VCP) |
| METTL21E | 403183 | 4832428D23Rik, Gm991 | Protein-lysine methyltransferase METTL21E | Lysine (VCP) |
| METTL22 | 79091 | C16orf68 | Methyltransferase-like protein 22 | Lysine (Kin17) |
| METTL23 | 124512 | C17orf95, MRT44 | Methyltransferase-like protein 23 | Unknown |
|
| ||||
| METTLs of unknown function | ||||
| METTL7A | 25840 | AAM-B, AAMB | Methyltransferase-like protein 7A | Unknown |
| METTL7B | 196410 | ALDI | Methyltransferase-like protein 7B | Unknown |
| METTL17 | 64745 | METT11D1 | Methyltransferase-like protein 17, mitochondrial | Unknown |
| METTL25 | 84190 | C12orf26 | Methyltransferase-like protein 25 | Unknown |
| METTL26 | 84326 | C16orf13, JFP2 | Methyltransferase-like 26 | Unknown |
| METTL27 | 155368 | WBSCR27 | Methyltransferase-like protein 27 | Unknown |
Note.—The gene names, NCBI IDs, aliases, and preferred names are vertebrate METTL genes.