Table 2.
Conserved Domains within Each METTL Gene Based on Results from CD-Search and Batch CD-Search (NCBI).
| Superfamily | CD | Gene |
|---|---|---|
| AdoMet MTases superfamily | COG2263 | METTL5 |
| DREV | METTL9 | |
| DUF938 | METTL26 | |
| Methyltransf_11 | METTL7A, METTL7B | |
| Methyltransf_12 | METTL2, METTL6 | |
| Methyltransf_16 | METTL21A, METTL21D | |
| Methyltransf_25 | METTL2, METTL6, METTL7A, METTL8, METTL10, METTL12, METTL13, METTL27 | |
| Methyltransf_31 | METTL10 | |
| Methyltransf_32 | METTL25B | |
| Methyltransf_4 | METTL1 | |
| Methyltransf_PK | METTL11A | |
| Nnt1 | METTL20 | |
| PRK00050 | METTL15 | |
| No specific CD (superfamily only) | METTL11B, METTL16, METTL17, METTL18, METTL19, METTL21B, METTL21C, METTL21E, METTL22, METTL23, METTL25 | |
|
| ||
| MT-A70 superfamily | MT-A70 | METTL3, METTL14 |
| No specific CD (superfamily only) | METTL4 | |