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. 2021 Sep 4;38(12):5309–5327. doi: 10.1093/molbev/msab267

Table 3.

Selection Results, Variance Estimations,a and Best-Fit ML Models for All METTLs and Each Individual METTL Gene.

Gene R Z-test d NT ± SE d AA ± SE d S ± SE d N ± SE ENC ModelNT ModelAA
All 0.5 5.8*** 0.65 ± 0.01 0.82 ± 0.02 0.74 ± 0.005 0.62 ± 0.02 52.45 GTR + G + I LG + G
METTL1 0.8 23.38*** 0.36 ± 0.01 0.32 ± 0.02 0.83 ± 0.02 0.23 ± 0.02 53.60 GTR + G + I WAG + G
METTL2 0.7 22.02*** 0.4 ± 0.01 0.39 ± 0.02 0.79 ± 0.01 0.28 ± 0.02 51.09 GTR + G + I LG + G
METTL3 0.7 27.28*** 0.4 ± 0.01 0.4 ± 0.02 0.82 ± 0.01 0.28 ± 0.01 53.89 GTR + G LG + G
METTL4 0.6 12.93*** 0.49 ± 0.01 0.55 ± 0.02 0.78 ± 0.02 0.4 ± 0.02 50.78 T92 + G + I LG + G + I
METTL5 0.8 18.17*** 0.4 ± 0.01 0.42 ± 0.02 0.81 ± 0.02 0.28 ± 0.02 53.16 T92 + G LG + G
METTL6 0.8 20.0*** 0.39 ± 0.01 0.4 ± 0.02 0.81 ± 0.02 0.27 ± 0.02 51.25 GTR + G LG + G
METTL7A 0.6 12.02*** 0.52 ± 0.01 0.61 ± 0.02 0.78 ± 0.02 0.44 ± 0.02 54.10 K2 + G + I LG + G + I
METTL7B 0.6 10*** 0.53 ± 0.01 0.61 ± 0.03 0.8 ± 0.02 0.45 ± 0.02 54.92 JC + I LG + I
METTL8 Vertebrates only 50.53
METTL9 0.7 14.15*** 0.49 ± 0.01 0.54 ± 0.02 0.81 ± 0.01 0.39 ± 0.02 52.31 K2 + G + I LG + G + I
METTL10 0.7 12.85*** 0.47 ± 0.01 0.55 ± 0.02 0.75 ± 0.02 0.38 ± 0.02 54.78 T92 + G + I LG + G + I
METTL11A 0.7 18.84*** 0.45 ± 0.01 0.49 ± 0.02 0.8 ± 0.01 0.35 ± 0.02 51.79 K2 + G + I LG + G + I
METTL11B Vertebrates only 49.58
METTL12 0.6 9.02*** 0.54 ± 0.01 0.63 ± 0.03 0.76 ± 0.02 0.46 ± 0.02 53.23 K2 + I LG + G + I
METTL13 0.7 24.82*** 0.48 ± 0.01 0.56 ± 0.01 0.78 ± 0.01 0.39 ± 0.01 50.84 GTR + G + I LG + G
METTL14 0.7 29.64*** 0.37 ± 0.01 0.32 ± 0.02 0.83 ± 0.01 0.23 ± 0.01 53.61 GTR + G LG + G
METTL15 0.7 18.11*** 0.45 ± 0.01 0.48 ± 0.02 0.79 ± 0.01 0.34 ± 0.02 51.84 HKY + G + I LG + G + I
METTL16 0.6 18.45*** 0.49 ± 0.01 0.57 ± 0.02 0.79 ± 0.01 0.41 ± 0.01 53.99 HKY + G + I LG + G + I
METTL17 0.7 17.89*** 0.53 ± 0.01 0.61 ± 0.02 0.79 ± 0.01 0.44 ± 0.01 54.27 GTR + G LG + G + I
METTL18 0.7 13.1*** 0.5 ± 0.01 0.57 ± 0.02 0.78 ± 0.02 0.41 ± 0.02 52.54 T92 + G + I LG + G + I
METTL19 0.7 13.24*** 0.49 ± 0.01 0.56 ± 0.02 0.77 ± 0.01 0.41 ± 0.02 51.68 GTR + G + I LG + G + I
METTL20 0.7 14.86*** 0.45 ± 0.01 0.48 ± 0.03 0.77 ± 0.01 0.35 ± 0.02 52.27 K2 + G + I LG + G + I
METTL21A 0.6 17.06*** 0.48 ± 0.01 0.54 ± 0.02 0.78 ± 0.01 0.39 ± 0.02 54.38 K2 + G + I LG + G
METTL21B Vertebrates only 45.13
METTL21C Vertebrates only 54.33
METTL21D 0.7 13.23*** 0.47 ± 0.01 0.54 ± 0.02 0.76 ± 0.02 0.38 ± 0.02 54.89 T92 + G + I LG + G + I
METTL21E Chordates only 53.19
METTL22 0.6 15.33*** 0.5 ± 0.01 0.58 ± 0.02 0.79 ± 0.01 0.42 ± 0.02 53.77 T92 + G + I LG + G + I
METTL23 0.6 18.63*** 0.45 ± 0.01 0.5 ± 0.02 0.78 ± 0.01 0.35 ± 0.02 52.42 K2 + G + I LG + G
METTL25 0.6 16.26*** 0.5 ± 0.01 0.58 ± 0.02 0.76 ± 0.01 0.42 ± 0.01 50.58 T92 + G + I LG + G + I
METTL25B 0.7 17.41*** 0.5 ± 0.01 0.56 ± 0.02 0.79 ± 0.01 0.4 ± 0.01 51.20 GTR + G + I LG + G + I
METTL26 0.7 13.38*** 0.44 ± 0.01 0.49 ± 0.03 0.8 ± 0.02 0.34 ± 0.02 50.61 K2 + I LG + G + I
METTL27 0.5 4.12*** 0.55 ± 0.02 0.69 ± 0.03 0.68 ± 0.04 0.5 ± 0.03 48.47 JC LG

Note.—SE, standard error; R, average transition/transversion ratio; dNT, mean nucleotide distance; dAA, mean amino acid distance; dS, synonymous substitution distance; dN, nonsynonymous substitution distance; ENC, effective number of codons (codon bias) ranging from 61 (i.e., no bias) to 20 (i.e., maximum bias); ModelNT, best-fit maximum likelihood (ML) DNA model; ModelAA, best-fit ML protein model.

a

All SE values were calculated using the Bootstrap method with 1,000 replications.

***

P value < 0.001 in Z-test of purifying selection (i.e., HA: dN < dS).