Table 3.
Analysis | Contrast | pcluster-FWER | Cluster size (no. of voxels) | MNI coordinates |
||
---|---|---|---|---|---|---|
X | Y | Z | ||||
Difference in connectivity in Real iTBS arm due to intervention | Post-pre | 0.033 | 278 | 44 | 16 | 20 |
0.042 | 42 | 20 | −12 | 0 | ||
0.047 | 17 | 6 | 62 | 2 | ||
Pre-post | 0.962 | 3 | 26 | 67 | 17 | |
Difference in connectivity in Sham iTBS arm due to intervention | Post-pre | 0.179 | 15 | 45 | 48 | 35 |
Pre-post | 0.647 | 01 | 56 | 15 | 49 | |
Difference of subtraction connectivity maps (post-pre) of the two groups | Real-sham | 0.207 | 15 | 39 | 31 | 51 |
Sham-real | 0.849 | 25 | 45 | 48 | 36 | |
Difference of subtraction connectivity maps (post-pre) of the two groups (with clozapine status as a covariate) | Real-sham | 0.126 | 12 | 40 | 31 | 51 |
Sham-real | 0.905 | 1 | 77 | 49 | 22 | |
Relationship between change in connectivity and change in SANS total (whole group) | Direct | 0.077 | 23 | 69 | 37 | 29 |
0.077 | 16 | 72 | 33 | 36 | ||
0.077 | 09 | 51 | 60 | 31 | ||
Inverse | 0.975 | 3 | 25 | 62 | 21 | |
Relationship between change in connectivity and change in SANS total (real iTBS) | Direct | 0.684 | 1 | 39 | 65 | 20 |
Inverse | 0.275 | 7 | 51 | 77 | 42 | |
Relationship between change in connectivity and change in SANS total (sham iTBS) | Direct | 0.286 | 1 | 42 | 22 | 16 |
Inverse | 0.955 | 3 | 40 | 58 | 26 |
MNI = Montreal Neurological Institute, FWER = family wise error rate, iTBS = intermittent theta burst stimulation, SANS=Scale for Assessment of Negative Symptoms.
p is significant at </=0.05