Table 1. Summary of the Techniques Used in This Work.

technique	resolution (nm)	information
SIM,a structured illumination microscopy	100	cellular localization of fluorescently labeled organellesa
cryo-SXT, cryo-soft X-ray tomography	40	3D imaging of cryopreserved cells to monitor changes in morphology and organelle structure
XRF, X-ray fluorescence	100	2D cellular distribution and quantification of platinum and endogenous elements
XANES, X-ray absorption near edge structure	100	oxidation state of platinum

^aDetails of fluorophores in Table S1.