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. 2021 Nov 26;8:760989. doi: 10.3389/fsurg.2021.760989

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Copyright © 2021 Liu, Yang, Shi, Wen, Zhang, Wang, Hu, Shi, Cao, Guo and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreasing of caspase-1 and caspase-11 affect the cell activity of NRK-52E cells after H/R. (A) Effects of different concentrations of Z-YVAD-FMK on cell activity in normoxic state. (B) NRK-52E cell activity at different times of reoxygenation. (C) Effects of different concentrations of Z-YVAD-FMK on the cell activity after 6 h of H/R. (D) Expression of caspase-11 mRNA after caspase-11 siRNA transfection. (E) Expression of caspase-11 protein and statistical analysis after caspase-11 siRNA transfection. (F) Effect of caspase-1 inhibition by Z-YVAD-FMK and caspase-11 inhibition by siRNA on cell activity, as detected by CCK-8. *p < 0.05, **p < 0.01, ^##p < 0.05. Z = Z-YVAD-FMK; H/R, hypoxia/reoxygenation; R, reoxygenation; DMSO, dimethyl sulfoxide; Si-casp11, small interfering ribonucleic acid caspase-11; Si-NC, si-caspase-11 negative control; GAPDH, glyceraldehyde-phosphate dehydrogenase.