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. 2021 Nov 26;8:760989. doi: 10.3389/fsurg.2021.760989

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Copyright © 2021 Liu, Yang, Shi, Wen, Zhang, Wang, Hu, Shi, Cao, Guo and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Z-YVAD-FMK and si-caspase-11 on protein and mRNA expression in the NRK-52E cell culture model. (A) mRNA levels of NLRP3, caspase-1, caspase-11, GSDMD, IL-1β, and IL-18 in NRK-52E cells after H/R. (B) Protein expression and statistical analysis of NLRP3, pro-caspase-1, cleaved-caspase-1, cleaved-caspase-11, GSDMD, pro-IL-1β, cleaved-IL-1β and cleaved-IL-18 in NRK-52E cells after caspase-1 or caspase-11 inhibition. *p < 0.05, **p < 0.01. Z = Z-YVAD-FMK; H/R, hypoxia/reoxygenation; DMSO, dimethyl sulfoxide; Si-casp11, small interfering ribonucleic acid caspase-11; Si-NC, si-caspase-11 negative control; GSDMD, gasdermin D; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.