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. 2021 Nov 26;12:717744. doi: 10.3389/fphar.2021.717744

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Copyright © 2021 Yong, Zhang, Huang, Yang, Zhu, Qian, Tian, Liu, Wu, Xu, Chen, Zhao, Gao and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction and analysis of the protein-protein interaction (PPI) network. (A) The PPI network model. The related targets of P. frutescens for the treatment of CKD stages 3–5 were imported into the String 11.0 database to construct the PPI network. The PPI network information was input into Cytoscape 3.6.0 software to construct the PPI network model and adjusted according to the network topology analysis. (B) Key nodes in PPI network model. The key nodes in the PPI network model were screened with Degree ≥20, 27 key proteins in the PPI network were selected. (C) Key modules in the PPI network model. Modular analysis of the PPI network was carried out by using MCODE plugin. Two key protein modules were screened. Module A contains 20 targets and 101 interactions and module B contains 25 targets and 99 interactions.