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. Author manuscript; available in PMC: 2021 Dec 10.
Published in final edited form as: Hepatology. 2021 May 22;74(1):515–518. doi: 10.1002/hep.31790

FIG. 1.

FIG. 1.

Heterogeneity of monocyte-derived macrophages in NASH. In a mouse model of NAFLD, resident yolk sac-embryonic KCs are gradually lost, and this niche is subsequently repopulated by BM-derived monocytes. The resulting intrahepatic macrophage population is heterogeneous, consisting of many subsets including pre-monocyte-derived KCs and hepatic LAMs. Hepatic LAMs express osteopontin, are located in fibrotic zones, and possess a unique transcriptomic profile. What signals drive the differentiation of monocyte-derived KCs into hepatic LAMs is unclear. Whereas hepatic LAMs had a distinct ability to metabolize lipid compared to KCs, whether this has significance in their crosstalk with steatotic hepatocytes is also undefined.