Bacterial species	Relevant resistance tested
Escherichia coli	Ampicillin or amoxicillin Amox + clav Apramycin (not mastitis) 3rd gen cephalosporins (Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone, or ceftiofur) Cefoperazone (only mastitis) Colistin Enrofloxacin or Ciprofloxacin Gentamicin (not mastitis) Neomycin Paromomycin (not mastitis) Sulfa‐TMP Tetracyclines (oxy/doxy/chlor/tet) (not mastitis)
Klebsiella pneumoniae	Amox+clav 3rd gen cephalosporins (Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone, or ceftiofur) Colistin Enrofloxacin or Ciprofloxacin Neomycin Sulfa‐TMP
Staphylococcus aureus	Cefoxitin Cefoperazone Ceftiofur Enrofloxacin or Ciprofloxacin Erythromycin mecA gene Neomycin Oxacillin Penicillin Penicillin‐novobiocin Pirlimycin Sulfa‐TMP
Streptococcus uberis	Cefoperazone Ceftiofur Enrofloxacin or Ciprofloxacin Erythromycin Penicillin, Penicillin‐novobiocin Pirlimycin Spiramycin Sulfa‐TMP Tylosin
Streptococcus dysgalactiae	Cefoperazone Ceftiofur Enrofloxacin or Ciprofloxacin Erythromycin Penicillin Penicillin‐novobiocin Pirlimycin Spiramycin Sulfa‐TMP Tylosin
Pasteurella multocida	Ampicillin, amoxicillin Enrofloxacin, ciprofloxacin or danofloxacin Erythromycin Florfenicol Gamithromycin Gentamicin 3rd gen cephalosporins (Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone, or ceftiofur) Penicillin Tetracyclines (oxy/doxy/chlor/tet) Tildipirosin Tilmicosin Tulathromycin Tylosin
Mannheimia haemolytica	Ampicillin, amoxicillin Enrofloxacin, ciprofloxacin or danofloxacin Erythromycin Florfenicol Gamithromycin Gentamicin 3rd gen cephalosporins (Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone, or ceftiofur) Penicillin Tetracyclines (oxy/doxy/chlor/tet) Tildipirosin Tilmicosin Tulathromycin Tylosin
Histophilus somni	Ampicillin, amoxicillin Enrofloxacin, ciprofloxacin or danofloxacin Erythromycin Florfenicol Gamithromycin Gentamicin 3rd gen cephalosporins (Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone, or ceftiofur) Penicillin Tetracyclines (oxy/doxy/chlor/tet) Tildipirosin Tilmicosin Tulathromycin Tylosin
Mycoplasma bovis	Enrofloxacin or Ciprofloxacin Erythromycin Florfenicol Tetracyclines (oxy/doxy/chlor/tet) Tilmicosin Tulathromycin Tylosin
Moraxella bovis	3rd gen cephalosporins (Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone, or ceftiofur) Florfenicol Penicillin Tetracyclines (oxy/doxy/chlor/tet) Tulathromycin
Fusobacterium necrophorum	3rd gen cephalosporins (Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone, or ceftiofur) Enrofloxacin or Ciprofloxacin Florfenicol Penicillin Tetracyclines (oxy/doxy/chlor/tet) Tulathromycin
Trueperella pyogenes	Ampicillin, amoxicillin 3rd gen cephalosporins (Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone, or ceftiofur) Enrofloxacin or Ciprofloxacin Erythromycin Penicillin Sulfa‐TMP Tetracyclines (oxy/doxy/chlor/tet)