TABLE 4.
The genotype distribution and HWE of MTHFR A1298C polymorphism in this meta-analysis. The bold value is C/T T/T A/C C/C genotype data is incomplete, and HWE evaluation cannot be performed.
| First author/Year | Number of samples | Genotype of cases | Genotype of controls | HWE | |||||
|---|---|---|---|---|---|---|---|---|---|
| Cases/controls | A/A | A/C | C/C | A/A | A/C | C/C | Chi | p | |
| Kahleova [34] 2002 | 164/173 | 79 | 62 | 23 | 77 | 75 | 21 | 0.171 | 0.679 |
| Tylicki [44] 2005 | 90/90 | 38 | 43 | 9 | 36 | 45 | 9 | 0.880 | 0.3481 |
| Markan [52] 2007 | 153/133 | 99 | 43 | 11 | 112 | 17 | 4 | 8.277 | 0.004 |
| Ng [67] 2009 | 79/39 | 37 | 35 | 7 | 22 | 14 | 3 | 0.134 | 0.7143 |
| Wang [107] 2010 | 195/213 | 132 | 56 | 7 | 134 | 68 | 11 | 0.377 | 0.5393 |
| Wang [108] 2010 | 203/225 | 138 | 57 | 8 | 139 | 75 | 11 | 0.046 | 0.8297 |
| Demirel [109] 2011 | 50/50 | 25 | 19 | 6 | 14 | 33 | 3 | 7.494 | 0.0062 |
| Fowdar [76] 2012 | 368/386 | 165 | 151 | 52 | 162 | 173 | 51 | 0.201 | 0.6539 |
| Alghasham [79] 2012 | 26/250 | 15 | 11 | 144 | 106 | – | – | ||
| Wei [90] 2015 | 246/348 | 157 | 78 | 11 | 213 | 121 | 12 | 1.073 | 0.3003 |
| Liu [102] 2019 | 930/1074 | 679 | 229 | 22 | 801 | 250 | 23 | 0.448 | 0.5034 |
HWE, Hardy–Weinberg equilibrium.