TABLE 6.
Pooled results and sensitivity analysis of the association between MTHFR A1298C polymorphism and essential hypertension. The meaning of bold is in different subgroups, there are statistically significant gene models. In other words, it is the genetic model associated with EH.
| Variable | n (cases/controls) | CC vs. AA | AC vs. AA | CC + AC vs. AA | CC vs. .AC + AA | C vs. A | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P h / I 2 (%) | OR (95%CI) | P h / I 2 (%) | OR (95%CI) | P h / I 2 (%) | OR (95%CI) | P h / I 2 (%) | OR (95%CI) | P h / I 2 (%) | ||
| Overall | 11 (2,504/2,979) | 1.07 (0.84–1.37) | 0.814/0.0 | 0.94 (0.77–1.17) a | 0.010/56.9 | 0.98 (0.87–1.10) a | 0.004/62.7 | 1.12 (0.89–1.43) | 0.889/0.0 | 1.01 (0.86–1.18) a | 0.015/56.0 |
| Ethnicity | |||||||||||
| Caucasian | 6 (777/988) | 1.03 (0.74–1.44) | 0.994/0.0 | 0.84 (0.64–1.10) | 0.230/27.3 | 0.87 (0.71–1.07) | 0.245/26.4 | 1.14 (0.83–1.55) | 0.929/0.0 | 0.96 (0.82–1.11) | 0.724/0.0 |
| Asian | 5 (1,727/1,991) | 1.11 (0.77–1.60) | 0.292/19.2 | 1.05 (0.77–1.44) a | 0.007/71.9 | 1.038 (0.90–1.20) a | 0.002/76.5 | 1.11 (0.77–1.60) | 0.488/0.0 | 1.07 (0.80–1.43) a | 0.001/77.5 |
| Geographic region | |||||||||||
| Europe | 2 (243/212) | 1.12 (0.61–2.05) | 0.748/0.0 | 0.99 (0.56–1.76) | 0.199/39.3 | 0.98 (0.67–1.42) | 0.238/28.3 | 1.18 (0.66–2.10) | 0.988/0.0 | 1.03 (0.77–1.36) | 0.385/0.0 |
| Oceania | 2 (458/476) | 0.99 (0.66–1.49) | 0.923/0.0 | 0.87 (0.66–1.14) | 0.876/0.0 | 0.89 (0.69–1.160) | 0.941/0.0 | 1.07 (0.73–1.57) | 0.885/0.0 | 0.96 (0.79–1.16) | 0.979/0.0 |
| South Asia | 1 (153/113) | 3.11 (0.96–10.08) | – | 2.86 (1.53–5.34) | – | 2.91 (1.64–5.15) | – | 2.50 (0.78–8.04) | – | 2.60 (1.59–4.26) | – |
| East Asia | 3 (1,328/1,512) | 0.91 (0.58–1.42) | 0.554/0.0 | 0.95 (0.76–1.18) | 0.254/27.0 | 0.98 (0.83–1.15) | 0.186/40.6 | 0.93 (0.60–1.44) | 0.662/0.0 | 0.93 (0.75–1.15) | 0.171/43.4 |
| Western Asia | 2 (76/300) | 1.12 (0.24–5.19) | – | 0.57 (0.19–1.73) | 0.063/71.1 | 0.39 (0.17–0.89) | – | 2.14 (0.50–9.07) | – | 0.70 (0.39–1.26) | – |
| Southeast Asia | 1 (246/346) | 1.24 (0.54–2.89) | – | 0.88 (0.62–1.24) a | – | 0.91 (0.65–1.27) a | – | 1.30 (0.57–3.00) | – | 0.96 (0.72–1.28) a | – |
| Sensitivity analysis of high-quality and HWE studies | |||||||||||
| Overall | 5 (1,786/1,988) | 0.95 (0.71–1.29) | 0.867/0.0 | 0.95 (0.82–1.09) | 0.506/0.0 | 0.95 (0.83–1.09) | 0.451/0.0 | 1.01 (0.75–1.34) | 0.900/0.0 | 0.97 (0.86–1.08) | 0.470/0.0 |
| Ethnicity | |||||||||||
| Caucasian | 2 (458/476) | 0.99 (0.66–1.49) | 0.923/0.0 | 0.87 (0.66–1.14) | 0.876/0.0 | 0.89 (0.69–1.16) | 0.941/0.0 | 1.07 (0.73–1.57) | 0.885/0.0 | 0.96 (0.79–1.16) | 0.979/0.0 |
| Asian | 3 (1,328/1,512) | 0.91 (0.58–1.42) | 0.554/0.0 | 0.98 (0.83–1.16) | 0.254/27.0 | 0.98 (0.83–1.15) | 0.186/40.6 | 0.928 (0.60–1.44) | 0.662/0.0 | 0.97 (0.84–1.12) | 0.171/43.4 |
| Geographic region | |||||||||||
| Europe | – | – | – | – | – | – | – | – | – | – | – |
| Oceania | 2 (458/476) | 0.99 (0.66–1.49) | 0.923/0.0 | 0.87 (0.66–1.14) | 0.876/0.0 | 0.89 (0.69–1.16) | 0.941/0.0 | 1.07 (0.73–1.57) | 0.885/0.0 | 0.96 (0.79–1.16) | 0.979/0.0 |
| East Asia | 3 (1,328/1,512) | 0.91 (0.58–1.42) | 0.554/0.0 | 0.98 (0.83–1.16) | 0.254/27.0 | 0.98 (0.83–1.15) | 0.186/40.6 | 0.93 (0.60–1.44) | 0.662/0.0 | 0.97 (0.84–1.12) | 0.171/43.4 |
a
A random-effects model was used.
HWE, Hardy–Weinberg equilibrium.