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. 2021 Nov 26;15:771580. doi: 10.3389/fnins.2021.771580

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Copyright © 2021 Guida, Sanguigno, Mascolo, Calabrese, Serani, Molinaro, Lau, Annunziato and Formisano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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siSp1 reduced Sp1, KMT2A, H3K4-me3 and RNA-Pol II binding on REST A mouse promoter sequence in SOD1-G93A motor neuron-like NSC34 cells exposed to MeHg (100 nM). (A–D) ChIP analysis with antibodies for: (A) Sp1, (B) KMT2A, (C) H3K4-me3 and (D) RNA-Pol II of REST A mouse promoter sequence exposed to MeHg 100 nM in SOD1-G93A cells transfected with siSp1. Binding activity is graphically represented as the percentage of vehicle. Bars represent mean ± SD (n = 3). *p ≤ 0.05 versus Vehicle, ^#p ≤ 0.05 versus siCTL + MeHg 100 nM/24 h.