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. 2021 Nov 26;8:750333. doi: 10.3389/fnut.2021.750333

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Copyright © 2021 Pizarro, Kossatz, González, Gamero, Veza, Fernández, Gabaldón, de la Torre and Robledo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pearson correlation analysis in female mice exposed to alcohol-water and alcohol-synbiotic comparing behavioral parameters, including escalation (% baseline), relapse (% baseline), depression-like scores (immobility index), anxiety-like scores (buried marbles index), long-term memory (discrimination index in the NOR test) with gut microbial abundance, short-chain fatty acids (SCFA: butyric and propionic acids), tryptophan metabolites: Tryp (tryptophan), serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), kynurenine (KYN), and neurotransmitters including GABA, dopamine (DA) and noradrenaline (NA) concentrations in the prefrontal cortex (PFC) and hippocampus (HPC). Positive correlations are shown in black tones and negative correlations in red tones. Darker tones signify stronger correlations, with significance represented by asterisks (*p < 0.05, **p < 0.01).