Table 3.

Methylation and expression correlation analysis

Regulatory element	DMR			DEG		Correlation analysis
	Region	Genehancer ID	Direction (smokers–nonsmokers)	Target gene	Direction (smokers–nonsmokers)	P value
Promoter	chr12:108733790–108734067	GH12J108336	Hyper	CMKLR1	Down	0.0108
Promoter/enhancer	chr2:222312663–222313620	GH02J221447	Hyper	EPHA4	Up	0.0130
	chr2:74375246–74375595	GH02J074146	Hyper	AUP1	Down	0.0433
	chr12:108733790–108734067	GH12J108336	Hyper	CMKLR1	Down	0.0108
	chr12:48289327–48289770	GH12J047896	Hyper	DDX23	Down	0.0122
	chr11:126030937–126031289	GH11J126157	Hyper	FAM118B	Down	0.0181
	chr2:74375246–74375595	GH02J074146	Hyper	HTRA2	Down	0.0433
	chr22:22128415–22128928	GH22J021772	Hyper	IGLV5-52	Down	0.0424
	chr19:30158120–30158513	GH19J029660	Hyper	PLEKHF1	Down	0.0241
	chr11:116699588–116699946	GH11J116825	Hyper	SIDT2	Down	0.0159
	chr1:161513847–161514197	GH01J161539	Hyper	SLAMF7	Down	0.0324
	chr11:116699588–116699946	GH11J116825	Hyper	TAGLN	Down	0.0116
	chr1:92291397–92291719	GH01J091825	Hyper	TGFBR3	Down	0.0376
	chr5:372991–373651	GH05J000367	Hypo	AHRR	Up	0.0324
	chr3:98239609–98240661	GH03J098521	Hypo	CLDND1	Up	0.0220
	chr3:169757128–169757597	GH03J170037	Hypo	GPR160	Up	0.0131
	chr19:19928614–19928997	GH19J019816	Hypo	ZNF506	Up	0.0348
	chr19:38186831–38187042	GH19J037695	Hypo	ZNF793	Up	0.0194
	chr17:73684198–73684529	GH17J075683	Hypo	LLGL2	Down	0.0316
	chr11:67024748–67025170	GH11J067257	Hypo	RAD9A	Down	0.0420
	chr9:116164296–116164796	GH09J113396	Hypo	RGS3	Down	0.0001
	chr22:46442102–46442610	GH22J046040	Hypo	TTC38	Down	0.0179
	chr7:148723197–148723699	GH07J149026	Hypo	ZNF282	Down	0.0220