Table 2.
Tryptophan, kynurenine and the KYN/TRP-ratios on admission and after 7 days.
| On admission | After 7 days | Mean Δ | p-value | ||
|---|---|---|---|---|---|
| Survived (n = 81) | |||||
| Tryptophan (µmol/L) | 44.5 (37.3–51.8) | 46.8 (38.9–60.4) | 4.58 (±17.08) | 0.008 | |
| Kynurenine (µmol/L) | 5.39 (3.91–6.87) | 4.30 (3.36–5.40) | −1.00 (±2.54) | < 0.001 | |
| KYN/TRP ratio | 11.8 (8.5–17.1) | 9.2 (6.2–13.2) | −3.73 (±10.90) | < 0.001 | |
| Died (n = 24) | |||||
| Tryptophan (µmol/L) | 46.5 (38.0–52.5) | 46.0 (38.7–60.0) | 0.45 (±34.80) | 0.864 | |
| Kynurenine (µmol/L) | 5.60 (4.21–6.95) | 6.04 (4.34–9.11) | 1.22 (±3.25) | 0.170 | |
| KYN/TRP ratio | 11.7 (8.7–15.5) | 13.5 (9.3–17.9) | 1.01 (±7.51) | 0.909 |
Data are presented as medians (IQR) or mean (±standard deviation). Differences of median concentrations between admission and after 7 days were calculated with the Wilcoxon test. A p-value < 0.05 was considered statistically significant.