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. 2021 Nov 26;12:780780. doi: 10.3389/fgene.2021.780780

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Copyright © 2021 Zhang, He, Lei, Mao, Jiang, Ni, Yin, Zhong, Chen, Zheng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression and interconnectedness of the pyroptosis-related genes in osteosarcoma. (A) The heatmap showed the differential expressed PRGs between human osteosarcoma samples and normal muscle tissues (red: high expression level, blue: low expression level). (B) PPI network of differentially expressed PRGs (The red nodes indicate upregulated PRGs and the green nodes indicate downregulated PRGs) (C) Critical modules from the PPI network. (D) The correlation network of the differential expressed PRGs (red lines indicate positive correlation and blue lines indicate negative correlation). PRGs, pyroptosis-related genes.