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. Author manuscript; available in PMC: 2021 Dec 10.
Published in final edited form as: Am J Transplant. 2017 Mar 17;17(6):1455–1461. doi: 10.1111/ajt.14229

Figure 2:

Figure 2:

(A) Antibody to the Bw6 epitope with strong positive reactivity with the exception to B*46:01- and B*73:01-bearing beads. Several HLA-C locus-bearing beads display the same low-level MFI values as the B46 and B73. (B) The Bw6-positive beads, including B46 and B73 (shaded boxes), contain the LRNLRG sequence (Bw6 epitope) at residues 77–83 (dash-lined box). Both B*46:01 and B*73:01 differ from the remaining Bw6-bearing antigens by a valine instead of a glutamic acid at position 75 (V75) (B). (C) Of note, the selected HLA-C locus antigen beads (shaded boxes) all contain the Bw6 epitope (dash-lined box) as well as the V75 (solid-lined box) identical to B46 and B73.