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(A) Antibodies with positive reactivity to beads bearing B*15:02(B75) and B*51:02 but negative reactivity to B*15:11(B75)- and B*51:01-bearing beads. (B) Amino acid sequences reveal that B*51:01 and B*51:02 differ by a single amino acid at residue 171 (exon 3, α-helix), while sequence differences between B*15:02 and B*15:11 are numerous, located on both the floor of the groove and α-helix (C). Amino acid differences highlighted in boxes in (B) and (C).
