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. Author manuscript; available in PMC: 2021 Dec 10.
Published in final edited form as: Hum Immunol. 2017 May 30;78(7-8):471–480. doi: 10.1016/j.humimm.2017.05.007

Fig. 2.

Fig. 2.

Complement-mediated interference (a.k.a. “prozone” effect). The large C1qrs and C3d complex, bound to primary HLA antibody and residing on the surface of the bead, are thought to sterically block the binding of PE-conjugated anti-Ig secondary antibody.