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. 2021 Nov 8;6(21):e150060. doi: 10.1172/jci.insight.150060

Figure 2. IL-10 overexpression delays the onset of the protective immune CD4+ T cell response.

Figure 2

B6 and pMT-10 mice were infected with M. tuberculosis H37Rv via aerosol route and IL-10 overexpression induced after day 5 after infection. B6 mice maintained in the same conditions were used as controls. (A) Frequency and number of CD4+ T cells in the lungs of mice throughout infection. (B) Frequency and number of IFN-γ–producing CD4+ T cells after in vitro restimulation with the immunodominant ESAT-61–20 peptide. (C) IFN-γ protein in lung supernatants determined by ELISA. Data represent at least 3 independent experiments with 5 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001; ***P < 0.0001 by Student’s t test. NS: not significant.