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. 2021 Nov 22;6(22):e150999. doi: 10.1172/jci.insight.150999

Figure 6. SW memory/naive PR3+ B cell ratio and clinical manifestations in patients with PR3-AAV.

Figure 6

In participants with PR3-AAV (n = 105), the SW memory/naive PR3+ B cell ratio did not correlate with age (A), sex (B), or renal manifestations (C), but higher levels of CRP and ESR were associated with a ratio of more than 1 (D). The ratio did not correlate with disease activity as assessed by BVAS/WG (E). Associations with complete remission definitions (F), future relapse and severe relapse (G), and time-to-complete remission (H) are represented. When evaluating associations with remission, the patients that underwent crossover (n = 7) or experienced early treatment failure (n = 6) during the trial time were excluded from the analysis. Data represent median (25%–75% IQR), while histograms represent proportions. P values were determined by 2-tailed Mann-Whitney test, or Fisher’s test, where appropriate. Spearman’s test and the Kaplan-Meier method with the log-rank test were used to test correlations and time to event, respectively. *P < 0.05, **P < 0.01, ***P < 0.001.