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. 2021 Nov 22;6(22):e153732. doi: 10.1172/jci.insight.153732

Figure 4. Semaglutide reduces liver fibrosis and hepatic cytokine gene expression in Glp1rTie2+/+ mice but not in Glp1rTie2–/– mice.

Figure 4

Analysis of liver tissue from PCSK9+HFHC-fed mice treated with vehicle (Veh) or semaglutide (Sema) for 18 weeks: (A) Col1a1 versus Ppia expression, (B) Picrosirius red+ (PSR+) collagen staining quantification (n = 5), and (C) representative images (scale bar: 500 μm). (D) Liver tissue triglycerides (TG), (E) liver expression of Glp1r and metabolic regulators, and (F) inflammation markers versus Ppia (n = 6–14). Data are presented as mean ± SD, with individual data points shown. *P < 0.05 for Sema effect, 2-way ANOVA multiple-comparison test; #P < 0.05, 2-way ANOVA effect for treatment; ‡P < 0.05, 2-way ANOVA effect for genotype.