Table 3.
Summary of key outcomes in studies of stereotactic body radiation therapy and rectal hydrogel spacer for treatment of prostate cancer.
| Gastrointestinal toxicity | FFBF | ||||||
| Study | Perirectal distance (mm) | Early grade 2 | Early grade 3 | Late grade 2∗ | Late grade 3∗ | Rate | Follow-up (mo)∗ |
| Alongi, 2013[14] | — | — | 0/8 | 0/[5] | 0/[5] | 8/8 | [11] |
| Chen, 2020[15] | — | 18/250 | 0/250 | 10/250 | 1/250 | 241/250 | 36 |
| Cuccia, 2020[16] | 9.9 | 0/10 | 0/10 | — | — | ||
| Hwang, 2019[17]Hwang, 2018[18] | 9.6 | 2/50 | 0/50 | 0/50 | 0/50 | 50/50 | 20 |
| Jones, 2017[19]Folkert, 2017[20] | 11.7 | 1/44 | 0/44 | — | 0/44 | 44/44 | 12 |
| King, 2018[21] | — | 0/6 | 0/6 | — | — | — | — |
| Ogita, 2019[22] | — | 7/40 | 0/40 | — | — | — | — |
| Pryor, 2019[23]Wilton, 2017[24] | — | — | 0/80 | — | — | — | — |
| Ruggieri, 2014[25] | 14.5 | — | — | — | — | — | — |
| Saito, 2020[26] | — | — | — | — | — | — | — |
| Zelefsky, 2019[27] | — | — | — | 3/269 | — | — | — |