Table 1.
Oral and salivary gland adenoid cystic carcinoma developing distant metastasis more than 10 years after initial treatment.
| Case | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Author (year) | Ohara et al.[17] (2007) | Yeung et al.[22] (2009) | Falk et al.[18] (2011) | Coupland et al.[23] (2014) | Liu et al.[24] (2015) | Rafael et al.[25] (2016) | Portilla et al.[19] (2018) | Kamigaichi et al.[20] (2018) | Morassi et al.[21] (2020) | Present case (2021) |
| Age/ sex | 27/ F | 23/ F | 49/ M | 15/ F | 41/ M | 52/ M | 61/ M | 45/ F | 25/ M | 52/ M |
| Primary location/ metastasis | SMG/ NA | SMG/ NA | Tongue/ NA | SMG/ NA | PG/ NA | SMG/ NA | Lower lip/ NA | Gingiva/ NA | PG/ intraparotid LN | SLG/- |
| Size (mm) | NA | NA | NA | NA | NA | 25 | NA | NA | 25 | 45 |
| Initial treatment | Resection | Resection | Resection, RT | Resection, CRT | Resection, ND, RT | Resection, RT | Resection, RT | NA | Resection, ND | Resection, ND, CRT |
| Histological subtype | NA | Cribriform∗ | NA | Tubular, cribriform∗ | Tubular | Cribriform | Tubular | Tubular, cribriform | Tubular, cribriform | Cribriform |
| Recurrence/ time to recurrence | – | +/ 5, 10 yr | - | +/ 35 yr | +/ 9 yr | +/ 9 yr | - | - | - | - |
| Time to metastasis/ location | 14 yr/lung | 10 yr/lung | 10 yr/ lung, 15 yr/ pancreas | 38 yr/liver | 10 years/ lung | 10 yr/ lung, tongue, 12 yr /toe | 11 yr/ lung, liver, skin, brain, choroid | 5 yr/ cervical LN, 36 yr/ lung | 25 yr/brain | 20 yr/ lung, 22 yr/ skin, vertebrae |
| Treatment for metastasis | None † | None † | Surgery | Surgery | NA | CRT | RT | Surgery | Surgery, RT | Surgery, CRT |
| Prognosis after treatment for metastasis/ yr | Died with disease/4 yr | Alive with disease/4 yr | No evidence of disease/ 0.5 yr | No evidence of disease/ 0.5 yr | NA | Alive with disease/1 yr | NA | No evidence of disease/2 yr | NA | Died with disease/ 2 yr |