Table 3.
Clinical development of various repurposed drugs for the management of psoriasis.
| Drug/API | Therapeutic indication | Status | Study details | ClinicalTrials.gov identifier |
|---|---|---|---|---|
| Paclitaxel | Cancer | Completed | Study to measure the safety and efficacy of paclitaxel in micellar form for severe psoriasis treatment | NCT00006276 |
| Paclitaxel | Cancer | Completed | Study to assess the potency of SOR007 as an ointment in psoriasis | NCT03004339 |
| Bexarotene | Cancer | Completed | Study on bexarotene with small-band UVB for psoriasis | NCT00151008 |
| Ruxolitinib | Cancer | Completed | Open-label study of topical drug to investigate the safety and efficacy in treating psoriasis | NCT00617994 |
| Ruxolitinib | Cancer | Completed | Study design for the application of ruxolitinib phosphate cream in psoriasis | NCT00820950 |
| Ruxolitinib | Cancer | Completed | Study (dose ranging) design for the application of ruxolitinib phosphate cream in psoriasis | NCT00778700 |
| Tofacitinib | Rheumatoid arthritis | Completed | Study of tofacitinib ointment for chronic psoriasis | NCT01831466 |
| Tofacitinib | Rheumatoid arthritis | Completed | Study measuring the safety and efficacy of CP-690,550 in Asian participants with moderate-severe psoriasis | NCT01815424 |
| Tofacitinib | Rheumatoid arthritis | Completed | Topical tofacitinib for chronic psoriasis | NCT00678561 |
| Tofacitinib | Rheumatoid arthritis | Completed | Determination of the effects of escalating multiple doses in psoriasis | NCT01736696 |
| Tofacitinib | Rheumatoid arthritis | Completed | Phase III randomized 2B, placebo-controlled trial for the evaluation of safety and efficacy of CP-690, 550 and etanercept in psoriasis | NCT01241591 |
| Tofacitinib | Rheumatoid arthritis | Completed | Study of the mechanism of action of CP-690, 550 in the skin of patients with moderate to severe psoriasis | NCT01710046 |
| Baricitinib | Rheumatoid arthritis | Completed | Double blind trial of baricitinib in participants with moderate to severe psoriasis | NCT01490632 |
| Metformin | Diabetes | Not recruited | Study designed to assess the safety and efficacy of metformin for the treatment of moderate psoriasis | NCT02644954 |
| Metformin | Diabetes | Not recruited | Treatment of psoriasis associated with metabolic disorders | NCT03629639 |