Table 1.
Novel cytotoxic compounds of the fungal endophytes reported during 2016–2020.
| Chemical nature | Secondary metabolite | Cell lines | Activity (IC50) | Endophytic fungi | Host plant (T/M)b | Location | Reference |
|---|---|---|---|---|---|---|---|
| Chromones | Botryochromone (1) | KB | 43 μg/mL | Botryosphaeriaceae family (unidentified strain BCC 54265) | Polygonum odoratum(T) | Thailand | Isaka et al. (2018) |
| NCI–H187 | 18 μg/mL | ||||||
| Rhytidchromone A (2) | MCF-7 | 19.3 ± 2.5 μM | Rhytidhysteron rufulum | Bruguiera gymnorrhiza(M) | Thailand | Chokpaiboon et al. (2016) | |
| KATO-3 | 23.3 ± 1.1 μM | ||||||
| Rhytidchromone B (3) | KATO-3 | 21.4 ± 2.3 μM | |||||
| Rhytidchromone C (4) | KATO-3 | 16.8 ± 3.6 μM | |||||
| Rhytidchromone D (5) | MCF-7 | 17.7 ± 3.7 μM | |||||
| KATO-3 | 16.0 ± 1.9 μM | ||||||
| Secalonic acid derivative F-7 (6) | PC-3 | 10.38 ± 0.14 μM | Aspergillus aculeatus MBT 102 | Rosa damascene(T) | India | Farooq et al. (2020) | |
| MCF-7 | 12.97 ± 0.02 μM | ||||||
| HT-29 | 30.23 ± 0.54 μM | ||||||
| SW620 | 22.80 ± 0.14 μM | ||||||
| MDA-MB-231 | 16.60 ± 0.28 μM | ||||||
| PANC-1 | 06.86 ± 0.09 μM | ||||||
| FR-2 | 10.14 ± 0.43 μM | ||||||
| Pyrones | (R)-3,6-dihydroxy-8-methoxy-3-methylisochroman-4-one (07) | MV4-11 | 38.39 μM | Aspergillus fumigatus | Cordyceps sinensis(T) | China | Li et al. (2019a) |
| 8-methoxy-3-methylisochromane-3,6-diol (08) | MV4-11 | 30.00 μM | |||||
| Aspermicrone B (09) | HepG2 | 9.9 μM | Aspergillus micronesiensis | Kappaphycus alvarezii(T) | Vietnam | Luyen et al. (2019) | |
| 5,6-dihydro-4-methoxy-6-hydroxymethyl-2H-pyran-2-one (10) | HeLa | 15.60 ± 0.28 μM | Pestalotiopsis palmarum | Sinomenium acutum (Thunb.) (T) | China | Xiao et al. (2018) | |
| HCT116 | 24.35 ± 0.56 μM | ||||||
| A-549 | 47.82 ± 2.19 μM | ||||||
| Phomone D (11) | HL-60 | 0.65 μM | Phoma sp. YN02–P-3 | Sumbaviopsis J. J. Smith (T) | China | Sang et al. (2017) | |
| PC-3 | 1.09 μM | ||||||
| HCT-116 | 2.31 μM | ||||||
| Phomone E (12) | HL-60 | 1.04 μM | |||||
| PC-3 | 5.90 μM | ||||||
| HCT-116 | 9.84 μM | ||||||
| Pleospyrone A (13) | HepG2 | 5.07 μM | Pleosporales sp. Sigrf05 | Siraitia grosvenorii(T) | China | Lai et al. (2020) | |
| BGC-823 | 1.26 μM | ||||||
| NCI–H1650 | 15.1 μM | ||||||
| Daoy | 2.72 μM | ||||||
| Pleospyrone D (14) | NCI–H1650 | 29.6 μM | |||||
| Pleospyrone E (15) | HCT-116 | 1.17 μM | |||||
| HepG2 | 20.3 μM | ||||||
| BGC-823 | 20.7 μM | ||||||
| NCI–H1650 | 6.26 μM | ||||||
| Daoy | 19.9 μM | ||||||
| Rhizopycnin C (16) | A-549 | 25.5 μM | Rhizopycnis vagum Nitaf22 | Nicotiana tabacum(T) | China | Lai et al. (2016) | |
| HCT116 | 37.3 μM | ||||||
| Xylarione A (17) | MCF-7 | 18 ± 1.08 μM | Xylaria psidii | Aegle marmelos(T) | India | Arora et al. (2016) | |
| MIA-Pa-Ca-2 | 16 ± 1.09 μM | ||||||
| NCI–H226 | 25 ± 1.98 μM | ||||||
| HepG2 | 37 ± 1.99 μM | ||||||
| DU145 | 22 ± 1.12 μM | ||||||
| Isocoumarins | Oryzaein A (18) | NB4 | 4.2 μM | Aspergillus oryzae | Paris polyphylla var. yunnanensis(T) | China | Zhou et al. (2016) |
| A-549 | 6.5 μM | ||||||
| SHSY5Y | 7.6 μM | ||||||
| MCF-7 | 8.2 μM | ||||||
| Oryzaein B (19) | NB4 | 2.8 μM | |||||
| A-549 | 4.2 μM | ||||||
| SHSY5Y | 3.5 μM | ||||||
| PC-3 | 4.8 μM | ||||||
| MCF-7 | 3.0 μM | ||||||
| Oryzaein C (20) | NB4 | 7.9 μM | |||||
| MCF-7 | 5.5 μM | ||||||
| Oryzaein D (21) | A-549 | 6.8 μM | |||||
| SHSY5Y | 8.8 μM | ||||||
| MCF-7 | 6.5 μM | ||||||
| Aspergisocoumrin A (22) | MDA-MB-435 | 05.08 ± 0.88 μM | Aspergillus sp. HN15-5D | Acanthus ilicifolius(M) | China | Wu et al. (2019) | |
| HepG2 | 43.70 ± 1.26 μM | ||||||
| H460 | 21.53 ± 1.37 μM | ||||||
| MCF10A | 11.34 ± 0.58 μM | ||||||
| Aspergisocoumrin B (23) | MDA-MB-435 | 04.98 ± 0.74 μM | |||||
| MCF10A | 21.40 ± 1.71 μM | ||||||
| Palmaerone E (24) | HepG2 | 42.8 μM | Lachnum palmae | Przewalskia tangutica(T) | China | Zhao et al. (2018a) | |
| Xanthones | Asperanthone (25) | HepG2 | 35.5 ± 0.06 μM | Aspergillus sp. TJ23 | Hypericum perforatum L (T) | China | Qiao et al. (2018) |
| Xanthoquinodin B9 (26) | KB | 7.04 μM | Chaetomium globosum 7s-1 | Rhapis cochinchinensis (Lour.) Mart. (T) | Thailand | Tantapakul et al. (2020) | |
| MCF-7 | 18.4 μM | ||||||
| NCI–H187 | 0.98 μM | ||||||
| Chryxanthone A (27) | A-549 | 41.7 ± 1.9 μM | Penicillium chrysogenum AD-1540 | Grateloupia turuturu(M) | China | Zhao et al. (2018b) | |
| BT-549 | 20.4 ± 1.2 μM | ||||||
| HeLa | 23.5 ± 0.2 μM | ||||||
| HepG2 | 33.6 ± 1.4 μM | ||||||
| MCF-7 | 46.4 ± 1.2 μM | ||||||
| Chryxanthone B (28) | A-549 | 20.4 ± 0.9 μM | |||||
| THP-1 | 41.1 ± 0.5 μM | ||||||
| Incarxanthone B (29) | A375 | 8.6 ± 0.2 μM | Peniophora incarnata | Bruguiera gymnorrhiza(M) | China | Li et al. (2020a) | |
| MCF-7 | 6.5 ± 0.4 μM | ||||||
| HL-60 | 4.9 ± 0.2 μM | ||||||
| Chryxanthone C (30) | HeLa | 23.6 ± 2.1 μM | Paecilamyces sp. TE-540 | Nicotiana tabacum L. (T) | China | Li et al. (2020b) | |
| Phenalenone | Hispidulone B (31) | A-549 | 02.71 ± 0.08 μM | Chaetosphaeronema hispidulum | Dessert plant (T) | China | Zhang et al. (2020) |
| Huh7 | 22.93 ± 1.61 μM | ||||||
| HeLa | 23.94 ± 0.33 μM | ||||||
| Diphenyl ethers | Sinopestalotiollide A (32) | HeLa | 18.92 ± 0.77 μM | Pestalotiopsis palmarum | Sinomenium acutum (Thunb.) (T) | China | Xiao et al. (2018) |
| HCT116 | 15.69 ± 0.09 μM | ||||||
| A-549 | 31.29 ± 0.72 μM | ||||||
| Sinopestalotiollide B (33) | HeLa | 12.80 ± 0.16 μM | |||||
| HCT116 | 22.67 ± 0.59 μM | ||||||
| A-549 | 44.89 ± 1.26 μM | ||||||
| Sinopestalotiollide C (34) | HeLa | 14.66 ± 0.64 μM | |||||
| HCT116 | 18.49 ± 2.81 μM | ||||||
| A-549 | 36.13 ± 1.33 μM | ||||||
| Sinopestalotiollide D (35) | HeLa | 1.19 ± 0.02 μM | |||||
| HCT116 | 2.66 ± 0.08 μM | ||||||
| A-549 | 2.14 ± 0.05 μM | ||||||
| Unclassified Polyketide | Lijiquinone (36) | RPMI-8226 | 129 μM | Ascomycete sp. F53 | Taxus yunnanensis(T) | China | Cain et al. (2020) |
| (3E,8E,6S)-undeca-3,8,10-triene-1,6-diol (37) | H1975 | 10 μM | Cladosporium sp. OUCMDZ-302 | Excoecaria agallocha(M) | China | Wang et al. (2018) | |
| Cytosporaphenone A (38) | MCF-7 | 70 μM | Cytospora rhizophorae | Morinda officinalis(T) | China | Liu et al. (2017) | |
| HepG2 | 60 μM | ||||||
| Fusarielin J (39) | A2780 | 12.5 μM | Fusarium tricinctum | Aristolochia paucinervis(T) | Morocco | Hemphill et al. (2017) | |
| Fusarielin K (40) | A2780 | 36.5 μM | |||||
| Fusarielin L (41) | A2780 | 84.6 μM | |||||
| Sporulosaldein F (42) | LM3 | 39.2 μM | Paraphaeosphaeria sp. F03 | Paepalanthus planifolius(T) | Brazil | De Amorim et al. (2019) | |
| MCF-7 | 34.4 μM | ||||||
| Peyronetide A (43) | A2780S | 24.1 ± 0.8 μM | Peyronellaea sp. FT431 | Verbena sp. (T) | USA | Li et al. (2019b) | |
| A2780CisR | 28.3 ± 7.2 μM | ||||||
| TK-10 | 29.2 ± 2.9 μM | ||||||
| Peyronetide B (44) | A2780S | 21.5 ± 0.3 μM | |||||
| A2780CisR | 27.2 ± 1.3 μM | ||||||
| TK-10 | 22.7 ± 1.3 μM | ||||||
| Preussilide A (45) | L929 | 6.5 μM | Preussia similis | Globularia alypum(T) | Algeria | Noumeur et al. (2017) | |
| KB3.1 | 6 μM | ||||||
| A431 | 20.3 μM | ||||||
| A-549 | 60.3 μM | ||||||
| SKOV-3 | 22.6 μM | ||||||
| PC-3 | 47.7 μM | ||||||
| MCF-7 | 24.3 μM | ||||||
| U2OS | 7.03 μM | ||||||
| Preussilide B (46) | L929 | 17.3 μM | |||||
| KB3.1 | 11.3 μM | ||||||
| A431 | 35.1 μM | ||||||
| A-549 | 70.3 μM | ||||||
| SKOV-3 | 32.4 μM | ||||||
| PC-3 | 60.2 μM | ||||||
| MCF-7 | 22.1 μM | ||||||
| Preussilide C (47) | L929 | 9.1 μM | |||||
| KB3.1 | 2.5 μM | ||||||
| A431 | 10.1 μM | ||||||
| A-549 | 22.9 μM | ||||||
| SKOV-3 | 15.6 μM | ||||||
| PC-3 | 18.4 μM | ||||||
| MCF-7 | 7.3 μM | ||||||
| U2OS | 6.8 μM | ||||||
| Preussilide D (48) | L929 | 24.7 μM | |||||
| KB3.1 | 17.4 μM | ||||||
| A431 | 17.9 μM | ||||||
| A-549 | 47.9 μM | ||||||
| SKOV-3 | 20.19 μM | ||||||
| PC-3 | 45.4 μM | ||||||
| MCF-7 | 15.4 μM | ||||||
| Preussilide E (49) | L929 | 80 μM | |||||
| KB3.1 | 23 μM | ||||||
| A431 | 55.8 μM | ||||||
| A-549 | 41.2 μM | ||||||
| SKOV-3 | 29.1 μM | ||||||
| PC-3 | 41.2 μM | ||||||
| MCF-7 | 55.8 μM | ||||||
| Preussilide F (50) | L929 | 53.6 μM | |||||
| KB3.1 | 51.2 μM | ||||||
| U2OS | 22.2 μM | ||||||
| Meroterpenoids | Isocochlioquinone D (51) | SF-268 | 32.8 ± 0.5 μM | Bipolaris sorokiniana A606 | Pogostemon cablin(T) | China | Wang et al. (2016) |
| MCF-7 | 28.3 ± 1.1 μM | ||||||
| NCI–H460 | 42.6 ± 2.5 μM | ||||||
| HepG2 | 38.7 ± 1.1 μM | ||||||
| Isocochlioquinone E (52) | SF-268 | 17.2 ± 1.1 μM | |||||
| MCF-7 | 28.1 ± 0.7 μM | ||||||
| NCI–H460 | 31.1 ± 1.1 μM | ||||||
| HepG2 | 13.6 ± 0.5 μM | ||||||
| Cochlioquinone G (53) | SF-268 | 35.9 ± 1.3 μM | |||||
| MCF-7 | 21.1 ± 0.6 μM | ||||||
| NCI–H460 | 26.9 ± 2.8 μM | ||||||
| HepG2 | 11.3 ± 1.9 μM | ||||||
| Cochlioquinone H (54) | SF-268 | 6.4 ± 0.2 μM | |||||
| MCF-7 | 8.6 ± 0.2 μM | ||||||
| NCI–H460 | 15.5 ± 0.7 μM | ||||||
| HepG2 | 7.6 ± 0.1 μM | ||||||
| Bipolahydroquinone C (55) | NCI–H226 | 5.5 μM | Bipolaris sp. L1-2 | Lycium barbarum(T) | China | Long et al. (2019) | |
| MDA-MB-231 | 6.7 μM | ||||||
| Cochlioquinone I (56) | MDA-MB-231 | 8.5 μM | |||||
| Cochlioquinone K (57) | MDA-MB-231 | 9.5 μM | |||||
| Cochlioquinone L (58) | MDA-MB-231 | 7.5 μM | |||||
| Cochlioquinone M (59) | MDA-MB-231 | 5.6 μM | |||||
| Emeridone B (60) | SMMC-7721 | 18.80 ± 0.23 μM | Emericella sp. TJ29 | Hypericum perforatum(T) | China | Li et al. (2019c) | |
| SW-480 | 18.35 ± 0.53 μM | ||||||
| Emeridone D (61) | A-549 | 11.33 ± 0.82 μM | |||||
| SMMC-7721 | 8.19 ± 0.39 μM | ||||||
| SW-480 | 14.67 ± 1.12 μM | ||||||
| Emeridone F (62) | SMMC-7721 | 17.49 ± 0.59 μM | |||||
| SW-480 | 16.84 ± 1.08 μM | ||||||
| 11-dehydroxy epoxyphomalin A (63) | MCF-7 | 2.0 μM | Peyronellaea coffeaearabicae FT238 | Pritchardia lowreyana(T) | USA | Li et al. (2016) | |
| MDA468 | 1.3 μM | ||||||
| MDA-MB-231 | 2.2 μM | ||||||
| T24 | 1.8 μM | ||||||
| OVCAR5 | 1.8 μM | ||||||
| OVCAR4 | 1.4 μM | ||||||
| OVCAR3 | 0.5 μM | ||||||
| IGROV-1/Pt | 1.6 μM | ||||||
| A2780 CisR | 0.6 μM | ||||||
| A2780 | 0.8 μM | ||||||
| Rhizovarin A (64) | A-549 | 11.5 μM | Mucor irregularis | Rhizophora stylosa(M) | China | Gao et al. (2016) | |
| HL-60 | 09.6 μM | ||||||
| Rhizovarin B (65) | A-549 | 6.3 μM | |||||
| HL-60 | 5.0 μM | ||||||
| Rhizovarin E (66) | A-549 | 9.2 μM | |||||
| Isopenicin A (67) | SW480 | 07.91 ± 0.53 μM | Penicillium sp. sh18 | Isodon eriocalyx var. laxiflora(T) | China | Tang et al. (2019) | |
| SW620 | 08.63 ± 0.15 μM | ||||||
| HCT116 | 09.03 ± 0.61 μM | ||||||
| CaCo2 | 12.56 ± 0.91 μM | ||||||
| SMMC-7721 | 27.66 ± 0.88 μM | ||||||
| A-549 | 37.06 ± 2.24 μM | ||||||
| MCF-7 | 27.89 ± 0.70 μM | ||||||
| Isopenicin B (68) | SW480 | 11.60 ± 0.18 μM | |||||
| SW620 | 15.48 ± 1.39 μM | ||||||
| HCT116 | 14.95 ± 0.22 μM | ||||||
| CaCo2 | 20.34 ± 0.25 μM | ||||||
| SMMC-7721 | 33.49 ± 0.17 μM | ||||||
| MCF-7 | 33.05 ± 0.19 μM | ||||||
| Sesquiterpenoids | Fumagillene A (69) | MV4-11 | 8.40 ± 2.9 μg/mL | Aspergillus fumigatus | Ligusticum wallichii(T) | China | Li et al. (2020c) |
| MDA-MB-231 | 14.3 ± 5.8 μg/mL | ||||||
| Fumagillene B (70) | MV4-11 | 11.2 ± 3.6 μg/mL | |||||
| MDA-MB-231 | 17.3 ± 6.4 μg/mL | ||||||
| Proversilin C (71) | HL-60 | 7.30 ± 1.2 μM | Aspergillus versicolor F210 | Lycoris radiata(T) | China | Li et al. (2020d) | |
| SMMC-7721 | 12.6 ± 0.9 μM | ||||||
| A-549 | 15.0 ± 0.8 μM | ||||||
| MCF-7 | 11.8 ± 0.5 μM | ||||||
| SW-480 | 12.4 ± 0.4 μM | ||||||
| Proversilin E (72) | HL-60 | 9.90 ± 1.4 μM | |||||
| SMMC-7721 | 19.4 ± 0.7 μM | ||||||
| A-549 | 28.4 ± 1.2 μM | ||||||
| MCF-7 | 18.3 ± 1.2 μM | ||||||
| SW-480 | 16.4 ± 1.0 μM | ||||||
| Lithocarin B (73) | SF-268 | 41.68 ± 0.88 μM | Diaporthe lithocarpus A740 | Morinda officinalis(T) | China | Liu et al. (2019a) | |
| MCF-7 | 37.68 ± 0.30 μM | ||||||
| HepG2 | 48.33 ± 0.10 μM | ||||||
| A-549 | 53.36 ± 0.91 μM | ||||||
| Lithocarin C (74) | SF-268 | 69.46 ± 7.08 μM | |||||
| MCF-7 | 97.71 ± 0.72 μM | ||||||
| HepG2 | 79.43 ± 0.63 μM | ||||||
| (R,2E,4E)-6-((2S,5R)-5-ethyltetrahydrofuran-2-yl)-6-hydroxy-4-methylhexa-2,4-dienoic acid (75) | MV4-11 | 22.29 μM | Fusarium tricinctum | Ligusticum chuanxiong(T) | Morocco | Cao et al. (2020) | |
| HCT116 | 54.97 μM | ||||||
| MCF-7 | 93.47 μM | ||||||
| A-549 | 69.62 μM | ||||||
| (S,2E,4E)-6-((2S,5R)-5-ethyltetrahydrofuran-2-yl)-6-hydroxy-4-methylhexa-2,4-dienoic acid (76) | MV4-11 | 70.20 μM | |||||
| MCF-7 | 81.21 μM | ||||||
| Periconianone E (77) | MCF-7 | 17.9 μM | Periconia sp. F-31 | Annona muricata(T) | China | Liu et al. (2016a) | |
| Periconianone H (78) | HeLa | 16.5 μM | |||||
| Pestathenol A (79) | HeLa | 78.2 μM | Pestalotiopsis theae | Camellia sinensis(T) | China | Guo et al. (2020) | |
| Pestathenol B (80) | HeLa | 88.4 μM | |||||
| Rhinomilisin A (81) | L5178Y | 5.0 μM | Rhinocladiella similis | Acrostichums aureum(M) | Cameroon | Liu et al. (2019b) | |
| Rhinomilisin G (82) | L5178Y | 8.7 μM | |||||
| Merulinol C (83) | KATO-3 | 35.0 ± 1.20 μM | Basidiomycetous fungus XG8D | Xylocarpus granatum(M) | Thailand | Choodej et al. (2016) | |
| Merulinol D (84) | KATO-3 | 25.3 ± 0.82 μM | |||||
| Cerrenin D (85) | SF-268 | 41.01 ± 0.34 μM | Cerrena sp. A593 | Pogostemon cablin(T) | China | Liu et al. (2020a) | |
| MCF-7 | 14.34 ± 0.45 μM | ||||||
| NCI–H460 | 29.67 ± 0.81 μM | ||||||
| HepG2 | 44.32 ± 2.12 μM | ||||||
| 7-epi-merulin B (86) | HuCCA-1 | 37.46 ± 3.77 μM | Pseudolagarobasidium acaciicola | Bruguiera gymnorrhiza(M) | Thailand | Wibowo et al. (2016) | |
| A-549 | 24.75 ± 1.09 μM | ||||||
| MOLT-3 | 2.39 ± 0.95 μM | ||||||
| HepG2 | 8.91 ± 3.13 μM | ||||||
| HL-60 | 0.28 ± 0.18 μM | ||||||
| MDA-MB231 | 12.22 ± 9.26 μM | ||||||
| T47D | 22.25 ± 3.35 μM | ||||||
| MRC-5 | 17.92 ± 4.58 μM | ||||||
| 3-epi-merulin A (87) | MOLT-3 | 17.28 ± 3.66 μM | |||||
| HepG2 | 20.71 ± 3.50 μM | ||||||
| HL-60 | 12.09 ± 3.50 μM | ||||||
| MRC-5 | 17.83 ± 2.72 μM | ||||||
| Diterpenoid | (10S)-12,16-epoxy-17 (15 → 16)-abeo-3,5,8,12,15-abietapentaen-2,7,11,14-tetraone (88) | HL-60 | 12.54 ± 1.18 μM | Pestalotiopsis adusta | Clerodendrum canescens(T) | China | Xu et al. (2016) |
| Triterpenoids | Integracide H (89) | BT-549 | 1.82 μM | Fusarium sp. | Mentha longifolia L. (T) | Saudi Arabia | Ibrahim et al. (2016a) |
| SKOV-3 | 1.32 μM | ||||||
| KB | 0.18 μM | ||||||
| Integracide J (90) | BT-549 | 2.46 μM | |||||
| SKOV-3 | 3.01 μM | ||||||
| KB | 2.54 μM | ||||||
| Steroid | Demethylincisterol A5 (91) | A-549 | 11.05 μM | Aspergillus tubingensis YP-2 | Taxus yunnanensis(T) | China | Yu et al. (2019) |
| HepG2 | 19.15 μM | ||||||
| Macrolides | Myrothecine D (92) | K562 | 8.20 μM | Myrothecium roridum | Trachelospermum jasminoides (Lindl.) Lem (T) | China | Shen et al. (2019) |
| SW1116 | 0.57 μM | ||||||
| Myrothecine E (93) | K562 | 15.98 μM | |||||
| SW1116 | 11.61 μM | ||||||
| Myrothecine F (94) | K562 | 00.97 μM | |||||
| SW1116 | 10.62 μM | ||||||
| Myrothecine G (95) | K562 | 01.53 μM | |||||
| SW1116 | 04.25 μM | ||||||
| 16-hydroxymytoxin B (96) | K562 | 2.87 μM | |||||
| SW1116 | 0.18 μM | ||||||
| 14′-dehydrovertisporin (97) | K562 | 0.056 μM | |||||
| SW1116 | 0.200 μM | ||||||
| Epiroridin acid (98) | SF-268 | 0.751 ± 0.03 μM | Myrothecium roridum A553 | Pogostemon cablin(T) | China | Liu et al. (2016b) | |
| MCF-7 | 0.170 ± 0.01 μM | ||||||
| NCI–H460 | 0.360 ± 0.05 μM | ||||||
| HepG2 | 0.380 ± 0.03 μM | ||||||
| Myrothecine H (99) | SF-268 | 6.75 ± 0.22 μM | Paramyrothecium roridum | Morinda officinalis(T) | China | Liu et al. (2020b) | |
| HepG2 | 6.72 ± 0.27 μM | ||||||
| Myrothecine I (100) | SF-268 | 0.20 ± 0.01 μM | |||||
| HepG2 | 0.20 ± 0.03 μM | ||||||
| 7-O-Methylnigrosporolide (101) | L5178Y | 0.7 μM | Pestalotiopsis microspora | Drepanocarpus lunatus(M) | Cameroon | Liu et al. (2016c) | |
| A2780 | 28 μM | ||||||
| Pestalotioprolide C (102) | L5178Y | 39 μM | |||||
| Pestalotioprolide D (103) | L5178Y | 5.6 μM | |||||
| Pestalotioprolide E (104) | L5178Y | 3.4 μM | |||||
| A2780 | 1.2 μM | ||||||
| Pestalotioprolide F (105) | L5178Y | 3.9 μM | |||||
| A2780 | 12 μM | ||||||
| Pestalotioprolide G (106) | A2780 | 36 μM | |||||
| Pestalotioprolide H (107) | L5178Y | 11 μM | |||||
| Lactones | Asperlactone G (108) | A-549 | 65.3 ± 1.06 μM | Aspergillus sp. | Pinellia ternate(T) | China | Xin et al. (2019) |
| Asperlactone H (109) | A-549 | 23.3 ± 2.01 μM | |||||
| (−)-Asperteretone E (110) | AsPC-1 | 9.50 μM | Aspergillus terreus | Hypericum perforatum(T) | China | Deng et al. (2020) | |
| SW1990 | 11.7 μM | ||||||
| PANC-1 | 9.80 μM | ||||||
| (+)-Asperteretone E (111) | AsPC-1 | 9.90 μM | |||||
| SW1990 | 10.3 μM | ||||||
| PANC-1 | 15.6 μM | ||||||
| Hispidulactone F (112) | HepG2 | 61.05 μM | Chaetosphaeronema hispidulum (TS-8-1) | Dessert plant (T) | China | Zheng et al. (2020) | |
| Azaphilones | Chaephilone C (113) | HepG2 | 38.6 μM | Chaetomium globosum TY-2 | Polygonatum Sibiricum(T) | China | Song et al. (2020) |
| Isochromophilone A (114) | ACHN | 27 μM | Diaporthe sp. SCSIO 41011 | Rhizophora stylosa(M) | China | Luo et al. (2018) | |
| 786-O | 34 μM | ||||||
| OS-RC-2 | 45 μM | ||||||
| Isochromophilone D (115) | ACHN | 14 μM | |||||
| 786-O | 8.9 μM | ||||||
| OS-RC-2 | 13 μM | ||||||
| Isochromophilone F (116) | ACHN | 13 μM | |||||
| 786-O | 10 μM | ||||||
| OS-RC-2 | 38 μM | ||||||
| Isochromophilone C (117) | 786-O | 38 μM | |||||
| OS-RC-2 | 44 μM | ||||||
| Phomopsone C (118) | A-549 | 08.9 μMa | Phomopsis sp. CGMCC No.5416 | Achyranthes bidentata(T) | China | Yang et al. (2020a) | |
| MDA-MB-231 | 03.2 μMa | ||||||
| PANC-1 | 17.3 μMa | ||||||
| Alkaloids | Asperchalasin A (119) | A-549 | 55.5 ± 1.87 μM | Aspergillus sp. | Pinellia ternate(T) | China | Xin et al. (2019) |
| Asperchalasin B (120) | A-549 | 54.2 ± 1.22 μM | |||||
| Asperchalasin C (121) | A-549 | 47.2 ± 0.92 μM | |||||
| Asperchalasin D (122) | A-549 | 40.6 ± 1.30 μM | |||||
| Asperchalasin E (123) | A-549 | 55.2 ± 1.85 μM | |||||
| Asperchalasin F (124) | A-549 | 70.2 ± 1.76 μM | |||||
| Pchaeglobosal B (125) | MCF-7 | 8.59 ± 0.40 μM | Chaetomium globosum P2-2-2 | Ptychomitrium sp. (T) | China | Peng et al. (2020a) | |
| HepG2 | 7.09 ± 0.11 μM | ||||||
| CT26 | 1.04 ± 0.04 μM | ||||||
| HT29 | 9.90 ± 0.68 μM | ||||||
| A-549 | 6.92 ± 0.21 μM | ||||||
| Chaetomiamide A (126) | HL-60 | 35.2 μM | Chaetomium sp. | Cymbidium Goeringii(T) | China | Wang et al. (2017) | |
| Ascomylactam A (127) | MDAMB-435 | 4.9 μM | Didymella sp. CYSK-4 | Pluchea indica(M) | China | Chen et al. (2019) | |
| MDAMB-231 | 5.9 μM | ||||||
| SNB19 | 6.8 μM | ||||||
| HCT116 | 5.5 μM | ||||||
| NCIH460 | 4.4 μM | ||||||
| PC-3 | 5.7 μM | ||||||
| Ascomylactam B (128) | MDAMB-435 | 12 μM | |||||
| MDAMB-231 | 6.6 μM | ||||||
| SNB19 | 18 μM | ||||||
| HCT116 | 4.5 μM | ||||||
| NCIH460 | 13 μM | ||||||
| PC-3 | 20 μM | ||||||
| Ascomylactam C (129) | MDAMB-435 | 7.8 μM | |||||
| MDAMB-231 | 5.1 μM | ||||||
| SNB19 | 7.8 μM | ||||||
| HCT116 | 4.2 μM | ||||||
| NCIH460 | 4.4 μM | ||||||
| PC-3 | 7.5 μM | ||||||
| Spirobrocazine C (130) | A2780 | 59 μM | Penicillium brocae MA-231 | Avicennia marina(M) | China | Meng et al. (2016) | |
| Brocazine G (131) | A2780 | 0.664 μM | |||||
| A2780 CisR | 0.661 μM | ||||||
| Penochalasin I (132) | MDA-MB-435 | 07.55 ± 0.71 μM | Penicillium chrysogenum V11 | Myoporum bontioides(M) | China | Huang et al. (2016) | |
| SGC-7901 | 07.32 ± 0.68 μM | ||||||
| A-549 | 16.13 ± 0.82 μM | ||||||
| Penochalasin J (133) | MDA-MB-435 | 36.68 ± 0.90 μM | |||||
| SGC-7901 | 37.70 ± 1.30 μM | ||||||
| A-549 | 35.93 ± 0.66 μM | ||||||
| Penochalasin K (134) | MDA-MB-435 | 4.65 ± 0.45 μM | Penicillium chrysogenum V11 | Myoporum bontioides(M) | China | Zhu et al. (2017a) | |
| SGC-7901 | 5.32 ± 0.58 μM | ||||||
| A-549 | 8.73 ± 0.62 μM | ||||||
| Penicisulfuranol A (135) | HeLa | 0.5 μM | Penicillium janthinellum HDN13-309 | Sonneratia caseolaris(M) | China | Zhu et al. (2017b) | |
| HL-60 | 0.1 μM | ||||||
| Penicisulfuranol B (136) | HeLa | 3.9 μM | |||||
| HL-60 | 1.6 μM | ||||||
| Penicisulfuranol C (137) | HeLa | 0.3 μM | |||||
| HL-60 | 1.2 μM | ||||||
| Chromenopyridin A (138) | A-549 | 14.7 μM | Penicillium nothofagi P-6 | Abies beshanzuensis(T) | China | Zhu et al. (2020) | |
| HeLa | 11.3 μM | ||||||
| 2′-aminodechloromaldoxin (139) | NCI–H460 | 18.63 ± 1.82 μM | Pestalotiopsis flavidula | Cinnamomum camphora(T) | China | Rao et al. (2019) | |
| SF-268 | 20.23 ± 2.15 μM | ||||||
| MCF-7 | 23.53 ± 2.33 μM | ||||||
| PC-3 | 20.48 ± 2.04 μM | ||||||
| 2′-aminodechlorogeodoxin (140) | NCI–H460 | 16.47 ± 1.63 μM | |||||
| SF-268 | 17.57 ± 2.12 μM | ||||||
| MCF-7 | 20.79 ± 2.39 μM | ||||||
| PC-3 | 19.43 ± 2.02 μM | ||||||
| Preussomerins | Chloropreussomerin A (141) | A-549 | 8.5 ± 0.9 μM | Lasiodiplodia theobromae ZJ-HQ1 | Acanthus ilicifolius(M) | China | Chen et al. (2016) |
| HepG2 | 13 ± 1 μM | ||||||
| HeLa | 19 ± 1 μM | ||||||
| MCF-7 | 5.9 ± 0.4 μM | ||||||
| HEK293T | 4.8 ± 0.2 μM | ||||||
| Chloropreussomerin B (142) | A-549 | 8.9 ± 0.6 μM | |||||
| HepG2 | 7.7 ± 0.1 μM | ||||||
| HeLa | 27 ± 3 μM | ||||||
| MCF-7 | 6.2 ± 0.4 μM | ||||||
| HEK293T | 11 ± 3.0 μM | ||||||
| p-terphenyls | Prenylterphenyllin F (143) | L-02 | 19.9 μM | Aspergillus candidus LDJ-5 | Rhizophora apiculate(M) | China | Zhou et al. (2020) |
| MGC-803 | 11.0 μM | ||||||
| HCT-116 | 09.3 μM | ||||||
| BEL-7402 | 12.4 μM | ||||||
| A-549 | 10.2 μM | ||||||
| SH-SY5Y | 10.4 μM | ||||||
| HeLa | 08.3 μM | ||||||
| HL-60 | 07.1 μM | ||||||
| Prenylterphenyllin G (144) | L-02 | 29.7 μM | |||||
| MGC-803 | 12.5 μM | ||||||
| HCT-116 | 16.9 μM | ||||||
| BEL-7402 | 12.6 μM | ||||||
| A-549 | 16.3 μM | ||||||
| SH-SY5Y | 12.4 μM | ||||||
| HeLa | 11.5 μM | ||||||
| Prenylterphenyllin H (145) | L-02 | 3.5 μM | |||||
| MGC-803 | 0.7 μM | ||||||
| HCT-116 | 0.5 μM | ||||||
| A-549 | 0.4 μM | ||||||
| SH-SY5Y | 0.6 μM | ||||||
| HeLa | 2.0 μM | ||||||
| U87 | 13.8 μM | ||||||
| Prenylterphenyllin I (146) | L-02 | 24.4 μM | |||||
| MGC-803 | 14.5 μM | ||||||
| HCT-116 | 14.7 μM | ||||||
| BEL-7402 | 11.1 μM | ||||||
| A-549 | 14.8 μM | ||||||
| SH-SY5Y | 16.7 μM | ||||||
| HeLa | 11.4 μM | ||||||
| Prenylterphenyllin J (147) | MGC-803 | 8.10 μM | |||||
| HCT-116 | 6.20 μM | ||||||
| A-549 | 7.60 μM | ||||||
| SH-SY5Y | 15.6 μM | ||||||
| HeLa | 8.50 μM | ||||||
| K562 | 15.9 μM | ||||||
| Prenylcandidusin E (148) | L-02 | 16.7 μM | |||||
| MGC-803 | 16.3 μM | ||||||
| HCT-116 | 19.8 μM | ||||||
| BEL-7402 | 14.9 μM | ||||||
| A-549 | 19.1 μM | ||||||
| SH-SY5Y | 17.9 μM | ||||||
| HeLa | 14.0 μM | ||||||
| U87 | 10.3 μM | ||||||
| K562 | 05.0 μM | ||||||
| Prenylcandidusin G (149) | L-02 | 17.9 μM | |||||
| MGC-803 | 1.40 μM | ||||||
| HCT-116 | 0.90 μM | ||||||
| BEL-7402 | 16.0 μM | ||||||
| A-549 | 2.80 μM | ||||||
| SH-SY5Y | 2.20 μM | ||||||
| HeLa | 10.1 μM | ||||||
| HL-60 | 3.40 μM | ||||||
| Gliocladinin C (150) | Hep-2 | 0.18 μM | Chaetomium subaffine L01 | Potato (T) | China | Han et al. (2019) | |
| HepG2 | 0.12 μM | ||||||
| Cytochalasans | Diaporthichalasin D (151) | A-549 | 13.7 ± 2.3 μM | Diaporthe sp. SC-J0138 | Cyclosorus parasiticus(T) | China | Yang et al. (2020b) |
| HeLa | 15.3 ± 2.7 μM | ||||||
| HepG2 | 08.8 ± 1.7 μM | ||||||
| Diaporthichalasin E (152) | HepG2 | 30.6 ± 2.5 μM | |||||
| Diaporthichalasin F (153) | HeLa | 34.7 ± 5.6 μM | |||||
| HepG2 | 16.5 ± 2.2 μM | ||||||
| Diaporthichalasin H (154) | A-549 | 13.9 ± 2.1 μM | |||||
| HeLa | 20.0 ± 1.5 μM | ||||||
| HepG2 | 09.9 ± 1.6 μM | ||||||
| MCF–7 | 32.1 ± 1.5 μM | ||||||
| Multirostratin B (155) | HepG2 | 31.95 ± 1.86 μM | Phoma multirostrata | Parasenecio albus(T) | China | Peng et al. (2020b) | |
| CT26 | 27.40 ± 0.68 μM | ||||||
| Multirostratin E (156) | MCF-7 | 34.08 ± 5.88 μM | |||||
| HepG2 | 32.05 ± 1.54 μM | ||||||
| CT26 | 17.20 ± 0.23 μM | ||||||
| A-549 | 25.51 ± 0.83 μM | ||||||
| Multirostratin F (157) | MCF-7 | 22.29 ± 0.35 μM | |||||
| HepG2 | 23.02 ± 0.24 μM | ||||||
| CT26 | 19.20 ± 1.63 μM | ||||||
| A-549 | 43.22 ± 4.49 μM | ||||||
| Multirostratin G (158) | MCF-7 | 10.22 ± 0.43 μM | |||||
| HepG2 | 17.69 ± 0.27 μM | ||||||
| CT26 | 06.03 ± 0.85 μM | ||||||
| HT29 | 43.03 ± 1.79 μM | ||||||
| A-549 | 05.04 ± 0.18 μM | ||||||
| Multirostratin H (159) | MCF-7 | 31.52 ± 0.82 μM | |||||
| HepG2 | 20.85 ± 0.48 μM | ||||||
| CT26 | 21.89 ± 0.35 μM | ||||||
| HT29 | 16.30 ± 0.60 μM | ||||||
| A-549 | 26.63 ± 0.49 μM | ||||||
| Multirostratin I (160) | CT26 | 19.31 ± 0.40 μM | |||||
| HT29 | 24.09 ± 0.73 μM | ||||||
| A-549 | 36.58 ± 1.10 μM | ||||||
| Multirostratin J (161) | MCF-7 | 30.75 ± 1.48 μM | |||||
| HepG2 | 25.29 ± 3.91 μM | ||||||
| CT26 | 14.53 ± 0.13 μM | ||||||
| HT29 | 21.33 ± 1.19 μM | ||||||
| Ergocytochalasin A (162) | HepG2 | 21.32 ± 0.30 μM | Phoma multirostrata XJ-2-1 | Parasenecio albus(T) | China | Peng et al. (2020c) | |
| A-549 | 19.11 ± 0.99 μM | ||||||
| MCF-7 | 26.63 ± 0.13 μM | ||||||
| HCT116 | 22.28 ± 2.65 μM | ||||||
| HT-29 | 15.23 ± 0.67 μM | ||||||
| CT26 | 06.92 ± 0.71 μM | ||||||
| Jammosporin A (163) | MOLT-4 | 20 μM | Rosellinia sanctaecruciana | Albizia lebbeck(T) | India | Sharma et al. (2018a) | |
| Xylarichalasin A (164) | HL-60 | 17.3 ± 1.6 μM | Xylaria cf. curta | Solanum tuberosum(T) | China | Wang et al. (2019a) | |
| A-549 | 11.8 ± 0.2 μM | ||||||
| SMMC-7721 | 08.6 ± 0.2 μM | ||||||
| MCF-7 | 06.3 ± 0.1 μM | ||||||
| SW480 | 13.2 ± 0.3 μM | ||||||
| 19-epi-cytochalasin P1 (165) | HL-60 | 13.31 ± 0.13 μM | Xylaria cf. curta | Solanum tuberosum(T) | China | Wang et al. (2019b) | |
| 7-O-acetyl-6-epi-19,20-epoxycytochalasin P (166) | HL-60 | 37.16 ± 1.90 μM | |||||
| MCF-7 | 26.64 ± 1.37 μM | ||||||
| 7-O-acetyl-19,20-epoxycytochalasin D (167) | HL-60 | 25.83 ± 1.42 μM | |||||
| MCF-7 | 34.03 ± 2.10 μM | ||||||
| Other Hybrids | Gartryprostatin A (168) | MV4-11 | 7.20 μM | Aspergillus sp. GZWMJZ-258 | Garcinia multiflora(T) | China | He et al. (2019) |
| Gartryprostatin B (169) | MV4-11 | 10.0 μM | |||||
| Aureochaeglobosin B (170) | MDA-MB-231 | 7.6 ± 0.5 μM | Chaetomium globosum | Pinellia ternate(T) | China | Yang et al. (2018) | |
| Aureochaeglobosin C (171) | MDA-MB-231 | 10.8 ± 0.64 μM | |||||
| Cytorhizin B (172) | HepG2 | 29.4 ± 4.4 μM | Cytospora rhizophorae A761 | Morinda officinalis(T) | China | Liu et al. (2019c) | |
| MCF-7 | 30.1 ± 3.3 μM | ||||||
| SF-268 | 34.8 ± 1.4 μM | ||||||
| NCI–H460 | 32.8 ± 4.1 μM | ||||||
| Cytorhizin C (173) | HepG2 | 68.6 ± 8.2 μM | |||||
| MCF-7 | 58.6 ± 1.8 μM | ||||||
| SF-268 | 36.8 ± 5.1 μM | ||||||
| NCI–H460 | 54.7 ± 0.2 μM | ||||||
| Trichoderpyrone (174) | A-549 | 16.9 ± 1.3 μM | Trichoderma gamsii | Panax notoginseng (BurK.) F.H. Chen (T) | China | Chen et al. (2017) | |
| HepG2 | 30.8 ± 0.2 μM | ||||||
| HeLa | 33.9 ± 0.7 μM | ||||||
| Miscellaneous Compounds | Alternate C (175) | MDA-MB-231 | 20.1 μM | Alternaria alternata | Paeonia lactiflora(T) | China | Wang et al. (2019c) |
| MCF-7 | 32.2 μM | ||||||
| Nigronapthaphenyl (176) | HCT 116 | 9.62 ± 0.5 μM | Nigrospora sphaerica | Bruguiera gymnorrhyza(M) | Sri Lanka | Ukwatta et al. (2019) | |
| Varioloid A (177) | A-549 | 3.5 μg/mL | Paecilomyces variotii EN-291 | Grateloupia turuturu(M) | China | Zhang et al. (2016a) | |
| HCT116 | 6.4 μg/mL | ||||||
| HepG2 | 2.5 μg/mL | ||||||
| Altertoxin IV (178) | MG-63 | 14.81 μg/mL | Alternaria sp. G7 | Broussonetia papyrifera(T) | China | Zhang et al. (2016b) | |
| SMMC-7721 | 22.87 μg/mL | ||||||
| Asperxin A (179) | A-549 | 11.72 μg/mL | Aspergillus sp. Y-2 | Abies beshanzuensis(T) | China | Zhu et al. (2019) | |
| HeLa | 16.78 μg/mL | ||||||
| 6-formamidechetomin (180) | HeLa | 21.6 nM | Chaetomium sp. M336 | Huperzia serrata Trev. (T) | China | Yu et al. (2018) | |
| SGC-7901 | 23.0 nM | ||||||
| A-549 | 27.1 nM | ||||||
| Chaetominin A (181) | Hep-2 | 0.23 μM | Chaetomium subaffine L01 | Potato (T) | China | Han et al. (2019) | |
| HepG2 | 0.38 μM | ||||||
| Xylarolide A (182) | MIA-PA-CA-2 | 20 ± 0.17 μM | Diaporthe sp. | Datura inoxia(T) | India | Sharma et al. (2018b) | |
| MCF-7 | 30 ± 1.02 μM | ||||||
| PC-3 | 14 ± 0.12 μM | ||||||
| Diportharine A (183) | MIA-PA-CA-2 | 34 ± 1.32 μM | |||||
| PC-3 | 22 ± 0.83 μM | ||||||
| Hormonemate A (184) | HepG2 | 29.0 μM | Dothiora sp. | Launaea arborescens(T) | Spain | Pérez-Bonilla et al. (2017) | |
| MCF-7 | 15.6 μM | ||||||
| Hormonemate B (185) | HepG2 | 28.7 μM | |||||
| MCF-7 | 11.1 μM | ||||||
| Hormonemate C (186) | MCF-7 | 27.8 μM | |||||
| Hormonemate D (187) | HepG2 | 36.2 μM | |||||
| MCF-7 | 18.3 μM | ||||||
| Hormonemate E (188) | HepG2 | 26.2 μM | |||||
| MCF-7 | 19.0 μM | ||||||
| MiaPaca_2 | 36.4 μM | ||||||
| (13R,14S,15R)- 13-hydroxy-14-deoxyoxacy-clododecindione (189) | A-549 | 9.2 μM | Exserohilum rostratum | Gymnadenia conopsea(T) | China | Lin et al. (2018) | |
| Fusarithioamide B (190) | SK-MEL | 11.2 ± 0.95 μM | Fusarium chlamydosporium | Anvillea garcinii (Burm.f.) DC. (T) | Egypt | Ibrahim et al. (2018) | |
| KB | 6.9 ± 0.75 μM | ||||||
| BT-549 | 0.09 ± 0.05 μM | ||||||
| SKOV-3 | 1.23 ± 0.03 μM | ||||||
| MCF-7 | 0.21 ± 0.07 μM | ||||||
| HCT-116 | 0.59 ± 0.01 μM | ||||||
| Fusarithioamide A (191) | SK-MEL | 9.3 ± 0.86 μM | Fusarium chlamydosporium | Anvillea garcinia (Burm.f.) DC. (T) | Egypt | Ibrahim et al. (2016b) | |
| KB | 7.7 ± 0.95 μM | ||||||
| BT-549 | 0.4 ± 0.07 μM | ||||||
| SKOV-3 | 0.8 ± 0.01 μM | ||||||
| 9-desmethylherbarine (192) | WI38 | 10.3 μM | Fusarium solani | Aponogeton undulatus(T) | Bangladesh | Chowdhury et al. (2017) | |
| NCI HI975 | 30.72 μM | ||||||
| MIA PaCa2 | 20.46 μM | ||||||
| MDA MB 231 | 27.73 μM | ||||||
| HeLa | 54.34 μM | ||||||
| 7-desmethylscorpinone (193) | WI38 | 0.96 μM | |||||
| NCI HI975 | 1.51 μM | ||||||
| MIA PaCa2 | 0.98 μM | ||||||
| MDA MB 231 | 0.61 μM | ||||||
| HeLa | 5.84 μM | ||||||
| 7-desmethyl-6-methylbostrycoidin (194) | WI38 | 0.71 μM | |||||
| NCI HI975 | 0.73 μM | ||||||
| MIA PaCa2 | 0.64 μM | ||||||
| MDA MB 231 | 0.34 μM | ||||||
| HeLa | 6.42 μM | ||||||
| Penctrimertone (195) | HL-60 | 16.77 μM | Penicillium sp. T2-11 | Gastrodsia elata(T) | China | Li et al. (2020e) | |
| SMMC-7721 | 23.63 μM | ||||||
| A-549 | 28.62 μM | ||||||
| MCF-7 | 21.53 μM | ||||||
| SW480 | 39.32 μM | ||||||
| Cosmochlorin D (196) | HL60 | 6.1 μM | Phomopsis sp. N-125 | Ficus ampelasa(T) | Japan | Shiono et al. (2017) | |
| Cosmochlorin E (197) | HL60 | 1.8 μM | |||||
| Pyrenosetin A (198) | A-375 | 2.8 μM | Pyrenochaetopsis sp. FVE-001 | Fucus vesiculosus(M) | Germany | Fan et al. (2020a) | |
| HaCaT | 4.2 μM | ||||||
| Pyrenosetin B (199) | A-375 | 6.3 μM | |||||
| HaCaT | 35 μM | ||||||
| Pyrenosetin C (200) | A-375 | 140.3 μM | |||||
| HaCaT | 142.9 μM | ||||||
| Pyrenosetin D (201) | A-375 | 77.5 μM | Pyrenochaetopsis sp. FVE-087 | Fucus vesiculosus(M) | Germany | Fan et al. (2020b) | |
| HaCaT | 39.3 μM | ||||||
| Rhytidenone G (202) | Ramos | 17.98 μM | Rhytidhysteron rufulum AS21B | Azima sarmentosa(M) | Thailand | Siridechakorn et al. (2017) | |
| H1975 | 07.30 μM | ||||||
| Rhytidenone H (203) | Ramos | 0.018 μM | |||||
| H1975 | 0.252 μM | ||||||
| 3-demethyl-3-(2-hydroxypropyl)-skyrin (204) | MCF-7 | 20.76 ± 3.41 μg/mL | Talaromyces sp. YE3016 | Aconitum carmichaeli(T) | China | Xie et al. (2016) | |
| Terezine E (205) | HUVEC | 28.02 μg/mLa | Mucor sp. | Centaurea stoebe(T) | USA | Abdou et al. (2020) | |
| K-562 | 27.31 μg/mLa | ||||||
| HeLa | 60.43 μg/mLa |
a
CC50
b
T: terrestrial plant; M: marine plant.