Fig. 3.

Photomicrographs of substantia nigra stained for TH immunoreactivity illustrating loss of dopaminergic neurons following 6-OHDA and preservation of those neurons following GDNF treatment (a). Quantitation of dopaminergic neurons in the substantia nigra demonstrates virtually complete protection of lesioned neurons (b). Data are presented as mean ​± ​SEM % of TH-positive neurons relative to the intact, non-lesioned hemisphere of 8 animals per group. Scale bars, 200 ​μm. Multiple comparisons were based on significant main effects of treatment resulting from the ANOVA described in Results: ∗∗p<0.01.