Fig. 5.

Normal weight gain and neurological performance is maintained in lesioned animals by implantation of GDNF devices. (a) Body weights of animals with and without GDNF treatment. (b–d) Performance in the cylinder, placing, and stepping tests are all significantly impaired at 2 and 4 weeks following intrastriatal injections of 6-OHDA. In contrast, performance on each of these tests is preserved by GNDF implants with treated animals performing comparably to pre-surgery levels (pre-implantation and pre-lesion). Data are presented as mean ​± ​SEM of 8 animals per group. Multiple comparisons were based on significant main effects or interactions resulting from ANOVAs that are described in Results: ∗∗p<0.01.