Fig. 8.

Implantation of 2 clinical-sized devices into the right putamen of minipigs delivers GDNF for 12 weeks and produces widespread delivery of GDNF (a–b) throughout the implanted striatum. GDNF delivery is also associated with a profound biological upregulation on dopaminergic function as determined by enhanced TH-immunoreactivity and quantitative optical densitometry in the striatum (c–d). Scale bars ​= ​5 ​mm. Data are presented as mean ​± ​SEM of 6 animals. ∗p<0.05; ∗∗p<0.01, Student's t test.