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. 2021 Feb 5;2:100017. doi: 10.1016/j.crphar.2021.100017

Fig. 2.

Fig. 2

Schematic diagram of the domain structure of ATM and ATR. Known structural domains are shown for each protein; FRAP–ATM–TRRAP domain (FAT), FAT C-terminal domain (FATC), Phosphatidylinositol 3-kinase-related kinase domain (PIKK), Tel1/ATM N-terminal motif (TAN), ATR interacting protein (ATRIP), and UVSB PI3 kinase, MEI-41 and ESR1 domain (UME). ATM and ATR consist of 3656 and 2644 amino acids respectively. (Adapted from Weber and Ryan, 2015).