. Author manuscript; available in PMC: 2021 Dec 30.

Published in final edited form as: Precis Cancer Med. 2021 Dec 30;4:38. doi: 10.21037/pcm-21-17

Table 1.

DPYD Polymorphisms with Established Prognostic Value for 5-FU Toxicity

DPYD variant	NCBI SNP reference	Nucleotide change	Protein effect	RR^a
DPYD*2A	rs3918290	1905+1G>A	Exon Skipping	2.87
DPYD*13	rs55886062	1679 T>G	Ile 560 Ser	4.3
c.2846A>T	rs67376798	2846 A>T	Asp 949 Val	3.11
HapB3	s56038477	1236 G>A	Glu 412 Glu, in haplotype B3	1.72

^a,

relative risk for overall grade ≥3 fluoropyrimidine-related toxicity compared with non-carriers of this variant (52). CPIC, Clinical Pharmacogenetics Implementation Consortium; HapB3, haplotype B3; RR, relative risk; NCBI, National Center for Biotechnology Information.