FIG. 1.

(A) Comparison of the chemical structures of Δ⁸-THC and Δ⁹-THC and the binding affinity (Ki) at the two cannabinoid receptors (showing near equal binding at both receptors). (B) Conversion of CBD into Δ⁸-THC. Note that altering the chemical conditions can produce more or less Δ⁹-THC (and even Δ¹⁰-THC). Moreover, the U.S. Cannabis Council report indicates that 94% of tested over-the-counter marketed Δ⁸-THC products contain Δ⁹-THC levels ≥0.3%, the legal limit designated by the 2018 Farm Bill.¹ Δ⁸-THC, delta-8-tetrahydrocannabinol; Δ⁹-THC, delta-9-tetrahydrocannabinol; CBD, cannabidiol.