Table 1. The physicochemical property of the flavonoids and the two control drugs.
Physicochemical Property | |||||||||
---|---|---|---|---|---|---|---|---|---|
Flavonoid | MW | NHBAs | NHBDs | TPSA | %Abs | MR | log S | LogD | LogP |
1 | 270.24 | 5 | 3 | 90.9 | 77.64 | 73.99 | -3.595 | 0.487 | 2.577 |
2 | 270.24 | 5 | 3 | 90.90 | 77.64 | 73.99 | -3.578 | 0.583 | 2.577 |
3 | 272.25 | 5 | 4 | 97.99 | 75.19 | 74.34 | -3.427 | 0.266 | 2.405 |
4 | 254.24 | 4 | 2 | 70.67 | 84.62 | 71.97 | -3.709 | 0.847 | 2.871 |
5 | 302.19 | 8 | 4 | 141.34 | 60.24 | 75.31 | -3.076 | -0.740 | 1.313 |
6 | 288.25 | 6 | 4 | 107.22 | 72.01 | 73.59 | -3.534 | 0.311 | 2.216 |
7 | 286.24 | 6 | 4 | 111.13 | 70.66 | 76.01 | -3.417 | 0.284 | 2.282 |
8 | 286.24 | 6 | 4 | 111.13 | 70.66 | 76.01 | -3.427 | 0.273 | 2.282 |
9 | 302.24 | 7 | 5 | 131.36 | 63.68 | 78.03 | -3.534 | 0.142 | 1.988 |
10 | 270.24 | 5 | 3 | 90.90 | 77.64 | 73.99 | -3.632 | 0.563 | 2.577 |
11 | 286.24 | 6 | 4 | 111.13 | 70.66 | 76.01 | -3.427 | 0.273 | 2.282 |
12 | 286.24 | 6 | 4 | 111.13 | 70.66 | 76.01 | -3.502 | 0.302 | 2.282 |
13 | 302.24 | 7 | 5 | 131.36 | 63.68 | 78.04 | -3.282 | 0.113 | 1.988 |
14 | 286.24 | 6 | 4 | 111.13 | 70.66 | 76.01 | -3.427 | 0.273 | 2.282 |
15 | 284.26 | 5 | 2 | 79.90 | 81.43 | 78.46 | -3.696 | 0.927 | 2.88 |
16 | 318.24 | 8 | 6 | 151.59 | 56.70 | 80.06 | -3.220 | -0.068 | 1.694 |
17 | 645.6 | 19 | 14 | 321.17 | -1.80 | 136.69 | -1.368 | 2.543 | -8.565 |
18 | 129.16 | 2 | 4 | 88.99 | 78.30 | 36.93 | -0.656 | -0.192 | -1.034 |