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Domain architectures of representative CRISPR effector proteins and RNA-mediated degradation of Cas13s. (A) Schematic representation showing the architecture of some proteins of class II CRISPR nucleases. The length of each protein is shown at the top scale. Schematic diagrams for gRNA and crRNAs of the Cas9 and Cas13, respectively, are indicated. (B) Schematic representation of the mechanism of action of RNA-mediated degradation of Cas13 nucleases in a cell model.
