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. 2021 Nov 26;12:774539. doi: 10.3389/fphar.2021.774539

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Copyright © 2021 Dai, Liu, Peng, Qu, Lin, Peng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Entinostat improves the motor function following SCI. Behavioral tests of SCI mice with entinostat (1, 5, or 10 mg/kg) or not and the grip strength of the right forepaw (A), left forepaw (B), and paired forepaws (C) was measured before the experiment and after surgery. (D) Measurement of the BMS score after SCI. Data are expressed as the mean ± SEM, n = 8. *p < 0.05, vs. the sham + vehicle group; #p < 0.05, vs. the SCI + vehicle group. BMS: basso mouse scale. SEM: standard error of the mean.