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. 2021 Nov 26;12:774539. doi: 10.3389/fphar.2021.774539

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Copyright © 2021 Dai, Liu, Peng, Qu, Lin, Peng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Entinostat suppresses HDAC1 and HDAC3 expressions in the spinal cord after SCI. (A) 7 days following SCI, HDAC1, HDAC2, HDAC3, HDAC4, HDAC6, HDAC8, and HDAC11 mRNA concentrations were measured. (B) Enzymatic activity of total HDAC was evaluated using the EpiQuik HDAC Activity/Inhibition Assay Kit. (C) WB analysis of HDAC1, HDAC2, and HDAC3 expressions in the spinal cord following SCI at 7 days. Data are expressed as the mean ± SEM, n = 5. *p < 0.05, vs. the sham + vehicle group; #p < 0.05, vs. the SCI + vehicle group.