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. 2021 Nov 26;12:774539. doi: 10.3389/fphar.2021.774539

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Copyright © 2021 Dai, Liu, Peng, Qu, Lin, Peng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Entinostat inhibits NLRP3 inflammasome activation in the spinal cord after SCI. NLRP3 inflammasome activation was measured in the spinal cord after SCI. (A) qPCR analysis of NLRP3 mRNA during 7 days post-SCI. (B) WB analysis of NLRP3, Caspase-1 expression in spinal cord after SCI at 7 days. Histogram analysis of the protein relative expression, vs. β-actin. (C) NLRP3/caspase-1 double staining was performed, and the nuclei were stained with DAPI. Scale bar: 50 μm. (D) ELISA analysis of the levels of TNF-α, IL-1β, and IL-18 in the spinal cord. (E) Caspase-1 activity was detected using Caspase-1 Activity Assay Kit after SCI. Data are expressed as the mean ± SEM, n = 5. *p < 0.05, vs. the sham + vehicle group; #p < 0.05, vs. the SCI + vehicle group.