Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 26;12:774539. doi: 10.3389/fphar.2021.774539

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Dai, Liu, Peng, Qu, Lin, Peng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Entinostat ameliorates OGD-induced NLPR3 inflammasome activation. In the OGD-induced neuronal damage model, enzymatic activity of total HDAC was evaluated using the EpiQuik HDAC Activity/Inhibition Assay Kit (A), and caspase-1 activity was detected using Caspase-1 Activity Assay Kit (B). (C) ELISA analysis of the levels of IL-1β and IL-18 in primal neurons. (D) WB analysis of NLRP3, caspase-1, and caspase-1 p 10 levels. (E) IF analysis of NLRP3 expression in the OGD model, Scale bar: 50 μm. Data are expressed as the mean ± SEM, n = 4. *p < 0.05, vs. the control group; #p < 0.05, vs. the OGD group.