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. 2021 Dec 10;7(50):eabk1131. doi: 10.1126/sciadv.abk1131

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 5. — Microglia sense and act on the early white matter by (1) clearing cellular debris from apoptotic oligodendrocytes through phosphatidylserine signaling, (2) phagocytosing live OPCs to regulate oligodendrocyte population dynamics, (3) removing abnormal myelin ultrastructure, (4) eliminating aberrantly targeted myelin, (5) promoting oligodendrogenesis, (6) fortifying mature oligodendrocytes and promoting myelination, and (7) sensing changes in neuronal activity to determine need for modification of myelin organization.