Fig. 1. Gata2 Ets motif variant dysregulates hematopoiesis through a hematopoietic cell–autonomous mechanism.

(A) Reciprocal transplantation of WT cells into WT and +9.5(Ets)^−/− recipients. (B) CBCs after transplant. NS, not significant; WBCs, white blood cells; RBCs, red blood cells; PLTs, platelets. (C) Multilineage repopulating activity 16 weeks after competitive transplant (n = 4 to 10 per genotype). (D) Analysis of donor-derived LSK (Lin⁻CD48⁻Sca1⁺Kit⁺), HSC (Lin⁻CD48⁻Sca1⁺Kit⁺CD150⁺), MPP (Lin⁻CD48⁻Sca1⁺Kit⁺CD150⁻), LS⁻K (Lin⁻Sca1⁻Kit⁺), MEP (Lin⁻Sca1⁻Kit⁺FcγR⁻CD34⁻), CMP (Lin⁻Sca1⁻Kit⁺FcγR⁻CD34⁺), and GMP (Lin⁻Sca1⁻Kit⁺FcγR⁺CD34⁺) within bone marrow 16 weeks after transplant (n = 4 to 9 per genotype) (two-tailed unpaired Student’s t test).