Skip to main content
. 2021 Dec 10;7(50):eabk3521. doi: 10.1126/sciadv.abk3521

Fig. 6. Combinatorial E-box;GATA and Ets motif mutation abrogates LT-HSC repopulating activity.

Fig. 6.

(A) Repopulating activity in peripheral blood 16 weeks after competitive transplant of total bone marrow (n = 9 to 10 per genotype) (two-tailed unpaired Student’s t test). (B) Percentage of donor-derived myeloid cells. (C) Percentage of donor-derived lymphoid cells. (D) Donor-derived hematopoiesis of LSK, HSC, and MPP within bone marrow 16 weeks after competitive transplant (n = 7 to 8 per genotype) (two-tailed unpaired Student’s t test). Donor-derived hematopoiesis of LS−K, CMP, GMP, and MEP within bone marrow 16 weeks after competitive transplant (n = 7 to 8 per genotype) (two-tailed unpaired Student’s t test). *P < 0.05, **P < 0.01, ***P < 0.001, two-tailed unpaired Student’s t test.