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Caspase-8 and cFLIP interactions and possible outcomes. Dimerization of caspase-8 induces apoptosis while inhibiting necroptosis. Caspase-8 dimerization with the proteolytically dead caspase-8 homolog cFLIPL blocks apoptosis but can still inhibit necroptosis. Dimerization with cFLIPS drives necroptosis.
