Table 2. Summary of Studies Included in Systematic Review.

CRP: C-reactive protein; PCT: procalcitonin; NS: neonatal sepsis

Study and year of publication	Study type	Purpose of study	Result/conclusion
Rashwan et al., 2019 [13]	Cross-sectional study	To determine the validity of biomarkers in screening for NS	CRP—more valuable in late-onset NS. PCT, presepsin, and hs-CRP, when used together, were early diagnostic markers for NS
Eschborn and Weitkamp, 2019 [14]	Systematic review	Review of kinetics and performance of PCT and CRP for diagnosis of NS	PCT and CRP perform better when measured serially to be used along with other clinical and laboratory data for initiation/stoppage of antibiotics
Ruan et al., 2018 [15]	Systematic review and meta-analysis	To evaluate the accuracy of diagnosis of NS using PCT and CRP combined or presepsin alone	PCT and CRP together improves the accuracy of the diagnosis of NS
Sharma et al., 2018 [16]	Literature review	Review of biomarkers for diagnosis of NS	CRP, PCT—most commonly used as sepsis markers. There is still a need to find an ideal biomarker
Liu et al., 2019 [17]	Meta-analysis	To assess the accuracy of CRP in neonatal septicemia	CRP can be used in detecting NS. But serum PCT has high specificity and sensitivity in diagnosing early NS
Thota et al., 2016 [18]	Observational study	To evaluate the role of PCT in the diagnosis of NS	PCT has a better correlation with confirmed sepsis. Therefore, it should be included in a full sepsis evaluation