Adjusted estimates of influenza vaccine effectiveness within influenza A(H1N1)pdm09 subclades, overall and stratified by age group, for participants enrolled in the US Influenza Vaccine Effectiveness Network for the 2019–2020 season. Only genetically characterized influenza A(H1N1)pdm09 viruses were included in this analysis. Vaccine effectiveness was calculated by comparing the odds of current season influenza vaccination in participants who tested positive for influenza and participants who tested negative for influenza, or (1-OR) × 100. Logistic regression models were adjusted for network site, age, presence of ≥1 high-risk conditions, and time in 2-week enrollment intervals.