Table 2.
Frailty Status and Cognitive Function Measurements Among 69 Older African American Adults With Human Immunodeficiency Virus (HIV) and 38 HIV-Seronegative Adults (Controls)
| Controls (N = 38) | HIV (N = 69) | P | |
|---|---|---|---|
| Frailty | |||
| Frailty score, median (IQR) | 1.5 (0, 3) | 2.0 (1, 3) | .34 |
| Frailty status, N (%) | |||
| Frail | 12 (31.6) | 25 (36.2) | .63 |
| Non-frail | 26 (68.4) | 44 (63.8) | |
| Frailty criteria: weight loss, N (%) | 8 (21.1) | 15 (21.7) | .93 |
| Frailty criteria: exhaustion, N (%) | 12 (31.6) | 43 (62.3) | .002 |
| Frailty Criteria: low activity, N (%) | 14 (36.8) | 24 (34.8) | .83 |
| Frailty criteria: slowness, N (%) | 12 (31.6) | 27 (39.1) | .44 |
| Frailty criteria: weakness, N (%) | 16 (42.1) | 22 (31.9) | .29 |
| NIH Toolbox cognition battery scores | |||
| Executive function, mean (SD) | |||
| Age corrected standard score | 94.0 (12.9) | 87.0 (17.2) | .03 |
| Fully corrected T-score | 46.9 (11.4) | 44.5 (12.3) | .33 |
| Attention, mean (SD) | |||
| Age corrected standard score | 83.7 (10.8) | 79.1 (10.9) | .04 |
| Fully corrected T-score | 42.8 (5.9) | 40.6 (6.5) | .09 |
| Working memory, mean (SD) | |||
| Age corrected standard score | 95.1 (14.1) | 88.8 (12.9) | .024 |
| Fully corrected T-score | 48.5 (10.4) | 44.5 (9.3) | .048 |
| Processing speed, mean (SD) | |||
| Age corrected standard score | 88.6 (19.5) | 83.2 (19.2) | .18 |
| Fully corrected T-score | 47.4 (12.9) | 43.5 (12.6) | .14 |
| Language, mean (SD) | |||
| Age corrected standard score | 103.9 (17.9) | 89.6 (17.0) | <.001 |
| Fully corrected T-score | 57.0 (10.7) | 49.8 (10.5) | .001 |
| Montreal Cognitive Assessment (MoCA) score, mean (SD) | 26.6 (2.6) | 24.2 (4.0) | .001 |
| Normal (≥26) | 30 (79.0) | 29 (42.0) | <.001 |
| Not normal (<26) | 8 (21.0) | 40 (58.0) |
Abbreviations: IQR, interquartile range; SD, standard deviation.