Table 2.

Summary of Unadjusted and Adjusted Models

Model	Hazard Ratio	95% Confidence Interval	P Value
Unadjusted model	2.26	1.47–3.46	<.001
Model adjusted for baseline covariatesa	1.72	1.08–2.75	.02
Adjusted model plus time-dependent covariatesb	1.68	1.05–2.70	.03

^aCovariates meeting criteria for inclusion in the multivariable model: nonischemic heart failure, history of diabetes, cytomegalovirus risk group, use of induction immunosuppression, rejection episode within the first posttransplant month, requirement for renal replacement therapy within the first posttransplant month, inpatient status at 1 month, white blood cell count at 1 month, use of trimethoprim-sulfamethoxazole, and transplant year.

^bTime-dependent covariates were rejection occurring after the first month and rejection specifically treated with lymphocyte-depleting therapy after the first month.